Drug profile

The FDA adverse-event record for Imidacloprid, Flumethrin

938 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid, Flumethrin. See the species affected, top reactions, and outcomes below.

938
adverse-event reports
3.6%
death-coded share
Dog
most-reported species
391
Lack of efficacy (ectoparasite) - flea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
938
Total Reports
34
Deaths Reported
3.6%
Death Rate

Active Ingredients

Imidacloprid, Flumethrin

Administration Routes

TopicalUnknownCutaneousOralSubcutaneous

Species Affected

Dog 791
Cat 146
Unknown 1

Most Affected Breeds

Retriever - Labrador 74
Domestic Shorthair 69
Dog (unknown) 57
Retriever - Golden 45
Cat (unknown) 37
Crossbred Canine/dog 36
Shepherd Dog - Australian 36
Shih Tzu 33
Terrier - Yorkshire 31
Chihuahua 30

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 391
Lack of efficacy (ectoparasite) - tick NOS 92
Vomiting 75
Behavioural disorder NOS 66
Pruritus 58
Scratching 52
Other abnormal test result NOS 50
Seizure NOS 43
Lack of efficacy (bacteria) - Borrelia 41
Lethargy (see also Central nervous system depression in Neurological) 41
Diarrhoea 37
Lack of efficacy (endoparasite) - heartworm 33

Outcome Breakdown

Outcome Unknown
539 (57.5%)
Ongoing
241 (25.7%)
Recovered/Normal
120 (12.8%)
Died
22 (2.3%)
Euthanized
12 (1.3%)
Recovered with Sequela
4 (0.4%)

Imidacloprid, Flumethrin Adverse Event Insights

938 reports name Imidacloprid, Flumethrin; 34 recorded a death outcome (3.6% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid, Flumethrin. Administration routes: Topical, Unknown, Cutaneous, Oral.

By species: Dog (791 reports), Cat (146 reports), Unknown (1 reports). By breed: Retriever - Labrador (74), Domestic Shorthair (69), Dog (unknown) (57).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (391), Lack of efficacy (ectoparasite) - tick NOS (92), Vomiting (75), Behavioural disorder NOS (66). Outcome, 938 coded reports: Outcome Unknown leads at 57.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.