Drug profile

The FDA adverse-event record for Imepitoin

234 FDA reports name Imepitoin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#497 of 2,679
by report volume (all drugs)
234
adverse-event reports
1.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imepitoin ranks #497 of 2679 by total reports (234) and #1047 of 1130 by death-coded share (1.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#497
This drug, reports of 2679
#1047
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imepitoin has 234 reports now versus 217 in that prior snapshot: 17 more (7.8%).

Report change
+17
Death-coded reports
+1
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imepitoin changes

Signature read: Imepitoin's 1.3% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
234
Total Reports
3
Deaths Reported
1.3%
Death-coded share of reports

Active Ingredients

Imepitoin

Administration Routes

OralUnknown

Species Affected

Dog 234

Most Affected Breeds

Dog (unknown) 27
Retriever - Labrador 26
Dog (other) 15
Crossbred Canine/dog 10
Beagle 10
Retriever - Golden 10
Shepherd Dog - German 9
Dachshund (unspecified) 9
Shih Tzu 8
Shepherd Dog - Australian 7

Most Reported Reactions

Behavioural disorder NOS 31
Vomiting 27
Ataxia 23
Increased appetite 19
Aggression 18
Diarrhoea 16
Decreased appetite 14
Lethargy (see also Central nervous system depression in Neurological) 13
Drooling 11
Elevated alanine aminotransferase (ALT) 10
Destructive behaviour 8
Not eating 7

Outcome Breakdown

Recovered/Normal
140 (59.8%)
Outcome Unknown
90 (38.5%)
Euthanized
3 (1.3%)
Recovered with Sequela
1 (0.4%)

Imepitoin: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Imepitoin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imepitoin (#497 of 2,679 by report volume); death-coded 1.3%. PlainBreed drug row · death-coded share stamp 1.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →