Drug profile

The FDA adverse-event record for Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5

13 FDA reports name Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2253 of 2,679
by report volume (all drugs)
13
adverse-event reports
69.2%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5 ranks #2210 of 2679 by total reports (13). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2210
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5 has 13 reports now versus 12 in that prior snapshot: 1 more (8.3%).

Report change
+1
Death-coded reports
+1
Death-coded share
+2.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5 changes

Signature read: Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5's 69.2% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
9
Deaths Reported
69.2%
Death-coded share of reports

Active Ingredients

Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5

Administration Routes

SubcutaneousUnknown

Species Affected

Cattle 13

Most Affected Breeds

Aberdeen Angus 6
Cattle (other) 3
Red Angus 2
Brangus 1
Simmental 1

Most Reported Reactions

Death 6
Lack of efficacy - NOS 6
Abortion 4
Found dead 2
Selenium toxicity signs 2
NT - Abnormal necropsy finding NOS 2
Respiratory signs 1
Lack of efficacy (bacteria NOS) 1
Lack of efficacy (virus) - herpesvirus NOS 1
Stillbirth 1
Liver disorder NOS 1
Infectious disease NOS 1

Outcome Breakdown

Died
9 (47.4%)
Ongoing
4 (21.1%)
Recovered/Normal
3 (15.8%)
Outcome Unknown
3 (15.8%)

Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ibr/Brsv/Pi3/Bvd Lv+Vib/Lep*5 (#2253 of 2,679 by report volume); death-coded 69.2%. PlainBreed drug row · death-coded share stamp 69.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →