Drug profile

The FDA adverse-event record for Ibr, Pi3, Brsv, Bvd

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ibr, Pi3, Brsv, Bvd. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
61.9%
death-coded share
Cattle
most-reported species
10
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
13
Deaths Reported
61.9%
Death Rate

Active Ingredients

Ibr, Pi3, Brsv, Bvd

Administration Routes

UnknownSubcutaneous

Species Affected

Cattle 21

Most Affected Breeds

Cattle (other) 11
Aberdeen Angus 7
Holstein-Friesian also known as Holstein 2
Cattle (unspecified) 1

Most Reported Reactions

Death 10
Lack of efficacy - NOS 9
Anaphylaxis 4
Not eating 3
Nasal discharge 2
Respiratory signs 2
Behavioural disorder NOS 2
Lameness 2
NT - Abnormal necropsy finding NOS 2
Lack of efficacy (bacteria) - NOS 2
Found dead 2
Death by euthanasia 1

Outcome Breakdown

Died
12 (36.4%)
Outcome Unknown
8 (24.2%)
Ongoing
6 (18.2%)
Recovered/Normal
6 (18.2%)
Euthanized
1 (3.0%)

Ibr, Pi3, Brsv, Bvd Adverse Event Insights

21 reports name Ibr, Pi3, Brsv, Bvd; 13 recorded a death outcome (61.9% of reported events, not a population-level mortality rate). Active ingredient: Ibr, Pi3, Brsv, Bvd. Administration routes: Unknown, Subcutaneous.

By species: Cattle (21 reports). By breed: Cattle (other) (11), Aberdeen Angus (7), Holstein-Friesian also known as Holstein (2).

Leading clinical signs: Death (10), Lack of efficacy - NOS (9), Anaphylaxis (4), Not eating (3). Outcome, 33 coded reports: Died leads at 36.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.