Drug profile

The FDA adverse-event record for Hydrocortisone Cream

13 FDA reports name Hydrocortisone Cream, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2251 of 2,679
by report volume (all drugs)
13
adverse-event reports
23.1%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Hydrocortisone Cream ranks #2210 of 2679 by total reports (13). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2210
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hydrocortisone Cream has 13 reports now versus 12 in that prior snapshot: 1 more (8.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hydrocortisone Cream changes

Signature read: 13 reports place Hydrocortisone Cream in the lower third of FDA AER volume (#2251 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
3
Deaths Reported
23.1%
Death-coded share of reports

Active Ingredients

Hydrocortisone Cream

Administration Routes

TopicalUnknownAuricular (Otic)

Species Affected

Dog 6
Cat 5
Human 2

Most Affected Breeds

Unknown 2
Domestic Shorthair 2
Maltese 2
Crossbred Canine/dog 1
Spaniel - King Charles Cavalier 1
Siamese 1
Persian 1
Collie - Border 1
Boxer (German Boxer) 1
Cat (other) 1

Most Reported Reactions

Lack of efficacy - NOS 4
Application site pruritus 3
Skin slough 3
Skin scab 3
Behavioural disorder NOS 3
Death by euthanasia 3
Accidental exposure 2
Pruritus 2
Application site erythema 2
Application site alopecia 2
Application site scab 2
Application site ulcer 2

Outcome Breakdown

Outcome Unknown
5 (38.5%)
Ongoing
4 (30.8%)
Euthanized
3 (23.1%)
Recovered/Normal
1 (7.7%)

Hydrocortisone Cream: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hydrocortisone Cream (#2251 of 2,679 by report volume); death-coded 23.1%. PlainBreed drug row · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →