Drug profile

The FDA adverse-event record for Hyaluronan

10 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Hyaluronan. See the species affected, top reactions, and outcomes below.

10
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
5
Corneal disorder NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
10
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Hyaluronan

Administration Routes

UnknownOphthalmicIntraocularIntravenous

Species Affected

Dog 9
Cat 1

Most Affected Breeds

Shih Tzu 5
Lhasa Apso 2
Rottweiler 1
Shepherd Dog - German 1
Domestic Shorthair 1

Most Reported Reactions

Corneal disorder NOS 5
Abnormal Schirmer tear test 5
Nasal dryness 5
Corneal ulcer 5
Neurogenic keratoconjunctivitis sicca (KCS) 5
Swollen eye 3
Eye redness 3
Ear pain 3
Blepharospasm 3
Crust 3
Swollen face (see also Skin) 3
Red eye 3

Outcome Breakdown

Recovered/Normal
8 (80.0%)
Outcome Unknown
2 (20.0%)

Hyaluronan Adverse Event Insights

10 reports name Hyaluronan; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Hyaluronan. Administration routes: Unknown, Ophthalmic, Intraocular, Intravenous.

By species: Dog (9 reports), Cat (1 reports). By breed: Shih Tzu (5), Lhasa Apso (2), Rottweiler (1).

Leading clinical signs: Corneal disorder NOS (5), Abnormal Schirmer tear test (5), Nasal dryness (5), Corneal ulcer (5). Outcome, 10 coded reports: Recovered/Normal leads at 80.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.