Drug profile

The FDA adverse-event record for Herbal Supplement

49 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Herbal Supplement. Species, reactions, and outcomes follow.

#1135 of 2,679
by report volume (all drugs)
49
adverse-event reports
16.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Herbal Supplement ranks #1131 of 2679 by total reports (49). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1131
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Herbal Supplement has 49 reports now versus 48 in that prior snapshot: 1 more (2.1%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Herbal Supplement changes

Signature read: Herbal Supplement's 16.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
49
Total Reports
8
Deaths Reported
16.3%
Death-coded share of reports

Active Ingredients

Herbal Supplement

Administration Routes

UnknownOral

Species Affected

Dog 43
Cat 6

Most Affected Breeds

Retriever - Labrador 12
Domestic Shorthair 5
Shih Tzu 3
Collie - Border 2
Beagle 2
Dachshund - Miniature 2
Retriever - Golden 2
Dog (unknown) 1
Boxer (German Boxer) 1
Corgi (unspecified) 1

Most Reported Reactions

Vomiting 11
Ataxia 6
Death by euthanasia 5
Weight loss 5
Diarrhoea 5
Anorexia 4
Elevated blood urea nitrogen (BUN) 4
Lack of efficacy - NOS 4
Not eating 4
Loose stool 4
Panting 4
Decreased appetite 4

Outcome Breakdown

Ongoing
21 (42.9%)
Outcome Unknown
11 (22.4%)
Recovered/Normal
9 (18.4%)
Euthanized
5 (10.2%)
Died
3 (6.1%)

Herbal Supplement Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Herbal Supplement (#1135 of 2,679 by report volume); death-coded 16.3%. PlainBreed drug row · death-coded share stamp 16.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →