Drug profile

The FDA adverse-event record for Heartworm Medication

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Heartworm Medication. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
15.0%
death-coded share
Dog
most-reported species
5
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
3
Deaths Reported
15.0%
Death Rate

Active Ingredients

Heartworm Medication

Administration Routes

UnknownOral

Species Affected

Dog 20

Most Affected Breeds

Retriever - Labrador 3
Schnauzer - Miniature 1
Shih Tzu 1
Retriever - Golden 1
Spitz - German Pomeranian 1
Collie - Border 1
Spaniel - Cocker American 1
Terrier (unspecified) 1
Mountain Dog - Bernese 1
Poodle - Standard 1

Most Reported Reactions

Vomiting 5
Diarrhoea 4
Not eating 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Seizure NOS 3
Elevated serum alkaline phosphatase (SAP) 3
Other abnormal test result NOS 2
Muscle shaking 2
Death by euthanasia 2
Elevated alanine aminotransferase (ALT) 2
Tonic-clonic seizure 2
Shaking 2

Outcome Breakdown

Recovered/Normal
10 (50.0%)
Outcome Unknown
4 (20.0%)
Ongoing
3 (15.0%)
Euthanized
2 (10.0%)
Died
1 (5.0%)

Heartworm Medication Adverse Event Insights

20 reports name Heartworm Medication; 3 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). Active ingredient: Heartworm Medication. Administration routes: Unknown, Oral.

By species: Dog (20 reports). By breed: Retriever - Labrador (3), Schnauzer - Miniature (1), Shih Tzu (1).

Leading clinical signs: Vomiting (5), Diarrhoea (4), Not eating (4), Lethargy (see also Central nervous system depression in 'Neurological') (3). Outcome, 20 coded reports: Recovered/Normal leads at 50.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.