Drug profile

The FDA adverse-event record for Grapriprant

11 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Grapriprant. See the species affected, top reactions, and outcomes below.

11
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
2
Decreased appetite - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Grapriprant

Administration Routes

OralUnknown

Species Affected

Dog 11

Most Affected Breeds

Catahoula Leopard Dog 2
Unknown 1
Maltese 1
Beagle 1
Chihuahua 1
Poodle - Toy 1
American Pit Bull Terrier 1
Sheepdog - Shetland 1
Boxer (German Boxer) 1
Crossbred Canine/dog 1

Most Reported Reactions

Decreased appetite 2
Diarrhoea 1
Inappetence 1
Halitosis 1
Oral ulceration 1
Elevated blood urea nitrogen (BUN) 1
High sodium-potassium ratio (Na:K ratio) 1
Abnormal adrenocorticotropic hormone (ACTH) stimulation test 1
Hypoadrenocorticism 1
Anxiety 1
Circling - neurological disorder (see also 'Behavioural disorders') 1
Increased respiratory rate 1

Outcome Breakdown

Outcome Unknown
6 (54.5%)
Ongoing
5 (45.5%)

Grapriprant Adverse Event Insights

11 reports name Grapriprant; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Grapriprant. Administration routes: Oral, Unknown.

By species: Dog (11 reports). By breed: Catahoula Leopard Dog (2), Unknown (1), Maltese (1).

Leading clinical signs: Decreased appetite (2), Diarrhoea (1), Inappetence (1), Halitosis (1). Outcome, 11 coded reports: Outcome Unknown leads at 54.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.