Drug profile

The FDA adverse-event record for Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate

150 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate. See the species affected, top reactions, and outcomes below.

150
adverse-event reports
16.7%
death-coded share
Pig
most-reported species
63
Anaphylaxis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
150
Total Reports
25
Deaths Reported
16.7%
Death Rate

Active Ingredients

Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate

Administration Routes

SubcutaneousUnknownIntramuscularSubconjunctivalTopical

Species Affected

Pig 126
Unknown 12
Human 8
Bat 2
Horse 2

Most Affected Breeds

Crossbred Porcine/Pig 117
Unknown 22
Pig (unknown) 7
Pig (other) 2
Quarter Horse 2

Most Reported Reactions

Anaphylaxis 63
Anaphylactoid reaction 28
Death 13
Anaphylactic-type reaction 10
Sudden death 9
Closure, Abnormal 9
Dyspnoea 6
Lack of efficacy - NOS 6
INEFFECTIVE, STERILIZATION 4
Accidental exposure 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Death by euthanasia 3

Outcome Breakdown

Recovered/Normal
104 (65.8%)
Outcome Unknown
28 (17.7%)
Died
22 (13.9%)
Euthanized
3 (1.9%)
Ongoing
1 (0.6%)

Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate Adverse Event Insights

150 reports name Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate; 25 recorded a death outcome (16.7% of reported events, not a population-level mortality rate). Active ingredient: Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate. Administration routes: Subcutaneous, Unknown, Intramuscular, Subconjunctival.

By species: Pig (126 reports), Unknown (12 reports), Human (8 reports). By breed: Crossbred Porcine/Pig (117), Unknown (22), Pig (unknown) (7).

Leading clinical signs: Anaphylaxis (63), Anaphylactoid reaction (28), Death (13), Anaphylactic-type reaction (10). Outcome, 158 coded reports: Recovered/Normal leads at 65.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.