Drug profile

The FDA adverse-event record for Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate

150 FDA reports name Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#631 of 2,679
by report volume (all drugs)
150
adverse-event reports
16.7%
death-coded share
Pig
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate ranks #631 of 2679 by total reports (150) and #313 of 1130 by death-coded share (16.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#631
This drug, reports of 2679
#313
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate has 150 reports now versus 150 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate changes

Signature read: death-coded report count at 25 is the most distinctive stamp on Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
150
Total Reports
25
Deaths Reported
16.7%
Death-coded share of reports

Active Ingredients

Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate

Administration Routes

SubcutaneousUnknownIntramuscularSubconjunctivalTopical

Species Affected

Pig 126
Unknown 12
Human 8
Bat 2
Horse 2

Most Affected Breeds

Crossbred Porcine/Pig 117
Unknown 22
Pig (unknown) 7
Pig (other) 2
Quarter Horse 2

Most Reported Reactions

Anaphylaxis 63
Anaphylactoid reaction 28
Death 13
Anaphylactic-type reaction 10
Sudden death 9
Closure, Abnormal 9
Dyspnoea 6
Lack of efficacy - NOS 6
INEFFECTIVE, STERILIZATION 4
Accidental exposure 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Death by euthanasia 3

Outcome Breakdown

Recovered/Normal
104 (65.8%)
Outcome Unknown
28 (17.7%)
Died
22 (13.9%)
Euthanized
3 (1.9%)
Ongoing
1 (0.6%)

Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (16.7% here), distinct from the volume row.

What to do with this drug

  • Compare Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Gonadotropin Releasing Factor (Gnrf) - Diphtheria Toxoid Conjugate (#631 of 2,679 by report volume); death-coded 16.7%. PlainBreed drug row · death-coded report count stamp 25 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →