Drug profile

The FDA adverse-event record for Gonadorelin Hydrochloride

58 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Gonadorelin Hydrochloride. See the species affected, top reactions, and outcomes below.

58
adverse-event reports
8.6%
death-coded share
Cattle
most-reported species
30
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
58
Total Reports
5
Deaths Reported
8.6%
Death Rate

Active Ingredients

Gonadorelin Hydrochloride

Administration Routes

IntramuscularUnknownSubcutaneous

Species Affected

Cattle 39
Unknown 16
Human 3

Most Affected Breeds

Unknown 19
Mixed (Cattle) 17
Aberdeen Angus 9
Cattle (other) 5
Holstein-Friesian also known as Holstein 3
Cattle (unspecified) 1
Hereford cattle 1
Simmental 1
Texas Longhorn 1
Red Angus 1

Most Reported Reactions

Lack of efficacy - NOS 30
INEFFECTIVE, ESTRUS SYNCHRONIZ 9
Uncoded sign 4
Reduced conception rate 3
No sign 3
Death 3
Caps, Abnormal 2
Vials, Leaking 2
Underfilling, Vials 2
Injection site reaction NOS 2
Accidental exposure 2
Physical label missing 2

Outcome Breakdown

Outcome Unknown
36 (70.6%)
Recovered/Normal
5 (9.8%)
Died
4 (7.8%)
Ongoing
3 (5.9%)
Euthanized
2 (3.9%)
Recovered with Sequela
1 (2.0%)

Gonadorelin Hydrochloride Adverse Event Insights

58 reports name Gonadorelin Hydrochloride; 5 recorded a death outcome (8.6% of reported events, not a population-level mortality rate). Active ingredient: Gonadorelin Hydrochloride. Administration routes: Intramuscular, Unknown, Subcutaneous.

By species: Cattle (39 reports), Unknown (16 reports), Human (3 reports). By breed: Unknown (19), Mixed (Cattle) (17), Aberdeen Angus (9).

Leading clinical signs: Lack of efficacy - NOS (30), INEFFECTIVE, ESTRUS SYNCHRONIZ (9), Uncoded sign (4), Reduced conception rate (3). Outcome, 51 coded reports: Outcome Unknown leads at 70.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.