Drug profile

The FDA adverse-event record for Glycosaminoglycan Polysulfate

806 FDA reports name Glycosaminoglycan Polysulfate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#216 of 2,679
by report volume (all drugs)
806
adverse-event reports
12.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glycosaminoglycan Polysulfate ranks #216 of 2679 by total reports (806) and #431 of 1130 by death-coded share (12.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#216
This drug, reports of 2679
#431
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glycosaminoglycan Polysulfate has 806 reports now versus 806 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glycosaminoglycan Polysulfate changes

Signature read: death-coded report count at 103 is the most distinctive stamp on Glycosaminoglycan Polysulfate's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
806
Total Reports
103
Deaths Reported
12.8%
Death-coded share of reports

Active Ingredients

Glycosaminoglycan Polysulfate

Administration Routes

IntramuscularSubcutaneousUnknownOphthalmicIntra-ArticularOralOther

Species Affected

Dog 666
Cat 66
Unknown 45
Horse 22
Human 6
Other 1

Most Affected Breeds

Retriever - Labrador 130
Crossbred Canine/dog 61
Unknown 53
Shepherd Dog - German 42
Retriever - Golden 39
Domestic (unspecified) 28
Boxer (German Boxer) 27
Dog (unknown) 24
Domestic Shorthair 21
Rottweiler 19

Most Reported Reactions

Vomiting 194
Anorexia 126
Diarrhoea 111
Depression 105
Other abnormal test result NOS 87
Death by euthanasia 68
Lethargy (see also Central nervous system depression in 'Neurological') 60
Elevated serum alkaline phosphatase (SAP) 52
Elevated alanine aminotransferase (ALT) 50
Weight loss 39
Injection site pain 38
Elevated blood urea nitrogen (BUN) 37

Outcome Breakdown

Recovered/Normal
121 (33.6%)
Ongoing
73 (20.3%)
Died
63 (17.5%)
Outcome Unknown
51 (14.2%)
Euthanized
40 (11.1%)
Recovered with Sequela
12 (3.3%)

Glycosaminoglycan Polysulfate: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Glycosaminoglycan Polysulfate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Glycosaminoglycan Polysulfate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glycosaminoglycan Polysulfate (#216 of 2,679 by report volume); death-coded 12.8%. PlainBreed drug row · death-coded report count stamp 103 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →