Drug profile

The FDA adverse-event record for Glycosaminoglycan Polysulfate

803 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glycosaminoglycan Polysulfate. See the species affected, top reactions, and outcomes below.

803
adverse-event reports
12.7%
death-coded share
Dog
most-reported species
193
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
803
Total Reports
102
Deaths Reported
12.7%
Death Rate

Active Ingredients

Glycosaminoglycan Polysulfate

Administration Routes

IntramuscularSubcutaneousUnknownOphthalmicIntra-ArticularOralOther

Species Affected

Dog 665
Cat 66
Unknown 45
Horse 20
Human 6
Other 1

Most Affected Breeds

Retriever - Labrador 129
Crossbred Canine/dog 61
Unknown 53
Shepherd Dog - German 42
Retriever - Golden 39
Domestic (unspecified) 28
Boxer (German Boxer) 27
Dog (unknown) 24
Domestic Shorthair 21
Rottweiler 19

Most Reported Reactions

Vomiting 193
Anorexia 126
Diarrhoea 111
Depression 105
Other abnormal test result NOS 87
Death by euthanasia 68
Lethargy (see also Central nervous system depression in 'Neurological') 60
Elevated serum alkaline phosphatase (SAP) 52
Elevated alanine aminotransferase (ALT) 50
Weight loss 39
Injection site pain 37
Elevated blood urea nitrogen (BUN) 37

Outcome Breakdown

Recovered/Normal
121 (33.9%)
Ongoing
73 (20.4%)
Died
62 (17.4%)
Outcome Unknown
49 (13.7%)
Euthanized
40 (11.2%)
Recovered with Sequela
12 (3.4%)

Glycosaminoglycan Polysulfate Adverse Event Insights

803 reports name Glycosaminoglycan Polysulfate; 102 recorded a death outcome (12.7% of reported events, not a population-level mortality rate). Active ingredient: Glycosaminoglycan Polysulfate. Administration routes: Intramuscular, Subcutaneous, Unknown, Ophthalmic.

By species: Dog (665 reports), Cat (66 reports), Unknown (45 reports). By breed: Retriever - Labrador (129), Crossbred Canine/dog (61), Unknown (53).

Leading clinical signs: Vomiting (193), Anorexia (126), Diarrhoea (111), Depression (105). Outcome, 357 coded reports: Recovered/Normal leads at 33.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.