Glucosamine Supplement

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104 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
104
Total Reports
12
Deaths Reported
1150.0%
Death Rate

Active Ingredients

Glucosamine Supplement

Administration Routes

OralUnknown

Species Affected

Dog 101
Cat 3

Most Affected Breeds

Retriever - Labrador 22
Shepherd Dog - German 15
Retriever - Golden 10
Dog (other) 4
Boxer (German Boxer) 3
Sheepdog - Shetland 3
Terrier - Bull - American Pit 2
Doberman Pinscher 2
Domestic Shorthair 2
Terrier - Jack Russell 2

Most Reported Reactions

Other abnormal test result NOS 26
Lethargy (see also Central nervous system depression in 'Neurological') 19
Vomiting 14
Diarrhoea 13
Decreased appetite 9
Weight loss 9
Emesis (multiple) 8
Anaemia NOS 8
Lack of efficacy - NOS 8
Polydipsia 7
Emesis 7
Abnormal radiograph finding 7

Outcome Breakdown

Ongoing
41 (39.4%)
Recovered/Normal
30 (28.8%)
Outcome Unknown
20 (19.2%)
Died
6 (5.8%)
Euthanized
6 (5.8%)
Recovered with Sequela
1 (1.0%)

Data Summary

Metric Value
Total adverse event reports 104
Reports involving death 12
Case-fatality rate (reported events) 1150.0%
Distinct species in reports 2
Distinct breeds in reports 20
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Glucosamine Supplement Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 104 adverse event reports referencing Glucosamine Supplement, including 12 reports in which the animal died — a 1150.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Glucosamine Supplement. Reported administration routes include Oral, Unknown. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Glucosamine Supplement reports are Dog (101 reports), Cat (3 reports), with Dog accounting for the largest share. Within those species, Retriever - Labrador (22), Shepherd Dog - German (15), Retriever - Golden (10) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Glucosamine Supplement are Other abnormal test result NOS (26), Lethargy (see also Central nervous system depression in 'Neurological') (19), Vomiting (14), Diarrhoea (13). Of the 104 reports with a coded outcome, Ongoing is the leading category at 39.4%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Glucosamine Supplement.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial