Drug profile

The FDA adverse-event record for Glucosamine Hydrochloride + Chondroitin Sulfate

29 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine Hydrochloride + Chondroitin Sulfate. See the species affected, top reactions, and outcomes below.

29
adverse-event reports
6.9%
death-coded share
Dog
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
29
Total Reports
2
Deaths Reported
6.9%
Death Rate

Active Ingredients

Glucosamine Hydrochloride + Chondroitin Sulfate

Administration Routes

OralUnknownParenteral

Species Affected

Dog 27
Cat 2

Most Affected Breeds

Retriever - Labrador 8
Corgi (unspecified) 2
Schnauzer - Miniature 2
Collie - Border 2
Beagle 2
Spaniel - King Charles Cavalier 1
Collie (unspecified) 1
Boxer (German Boxer) 1
Cattle Dog - Flanders (Bouvier) 1
Chihuahua 1

Most Reported Reactions

Vomiting 6
Diarrhoea 3
Weight loss 3
Abnormal radiograph finding 2
Emesis 2
Overdose 2
Lack of efficacy (endoparasite) - heartworm 2
Palpable mass NOS 1
Cough 1
Elevated liver enzymes 1
INEFFECTIVE, HEARTWORM LARVAE 1
Lack of efficacy (roundworm) 1

Outcome Breakdown

Outcome Unknown
12 (41.4%)
Recovered/Normal
7 (24.1%)
Ongoing
6 (20.7%)
Recovered with Sequela
2 (6.9%)
Euthanized
2 (6.9%)

Glucosamine Hydrochloride + Chondroitin Sulfate Adverse Event Insights

29 reports name Glucosamine Hydrochloride + Chondroitin Sulfate; 2 recorded a death outcome (6.9% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine Hydrochloride + Chondroitin Sulfate. Administration routes: Oral, Unknown, Parenteral.

By species: Dog (27 reports), Cat (2 reports). By breed: Retriever - Labrador (8), Corgi (unspecified) (2), Schnauzer - Miniature (2).

Leading clinical signs: Vomiting (6), Diarrhoea (3), Weight loss (3), Abnormal radiograph finding (2). Outcome, 29 coded reports: Outcome Unknown leads at 41.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.