Drug profile

The FDA adverse-event record for Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others

11 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others. See the species affected, top reactions, and outcomes below.

11
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
4
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others

Administration Routes

OralUnknown

Species Affected

Dog 11

Most Affected Breeds

Retriever - Labrador 2
Spaniel - Cocker American 2
Chow Chow 1
Crossbred Canine/dog 1
Dachshund - Miniature 1
Chihuahua 1
Terrier - Yorkshire 1
Terrier (unspecified) 1
Pit Bull 1

Most Reported Reactions

Emesis 4
Vomiting 2
Gagging 1
Lethargy (see also Central nervous system depression in 'Neurological') 1
Behavioural disorder NOS 1
Stomach upset 1
Scratching 1
Urinary incontinence 1
Elevated serum alkaline phosphatase (SAP) 1
Elevated creatine-kinase (CK) 1
Elevated cholesterol (total) 1
Other abnormal test result NOS 1

Outcome Breakdown

Recovered/Normal
8 (72.7%)
Outcome Unknown
2 (18.2%)
Recovered with Sequela
1 (9.1%)

Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others Adverse Event Insights

11 reports name Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine Hcl + Methylsulfonyl Methane + Creatine Monohydrate + Others. Administration routes: Oral, Unknown.

By species: Dog (11 reports). By breed: Retriever - Labrador (2), Spaniel - Cocker American (2), Chow Chow (1).

Leading clinical signs: Emesis (4), Vomiting (2), Gagging (1), Lethargy (see also Central nervous system depression in 'Neurological') (1). Outcome, 11 coded reports: Recovered/Normal leads at 72.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.