Drug profile

The FDA adverse-event record for Glucosamine Hcl, Chondroitin Sulfate & Manganese

117 FDA reports name Glucosamine Hcl, Chondroitin Sulfate & Manganese, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#719 of 2,679
by report volume (all drugs)
117
adverse-event reports
17.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine Hcl, Chondroitin Sulfate & Manganese ranks #717 of 2679 by total reports (117) and #277 of 1130 by death-coded share (17.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#717
This drug, reports of 2679
#277
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glucosamine Hcl, Chondroitin Sulfate & Manganese has 117 reports now versus 117 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glucosamine Hcl, Chondroitin Sulfate & Manganese changes

Signature read: death-coded report count at 21 is the most distinctive stamp on Glucosamine Hcl, Chondroitin Sulfate & Manganese's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
117
Total Reports
21
Deaths Reported
17.9%
Death-coded share of reports

Active Ingredients

Glucosamine Hcl, Chondroitin Sulfate & Manganese

Administration Routes

OralUnknown

Species Affected

Dog 93
Cat 22
Horse 2

Most Affected Breeds

Retriever - Labrador 21
Domestic Shorthair 15
Retriever - Golden 6
Shepherd Dog - German 5
Boxer (German Boxer) 4
Shepherd Dog - Australian 4
Terrier - Bull - American Pit 4
Shepherd (unspecified) 3
Shih Tzu 2
Great Pyrenees 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 32
Vomiting 19
Anorexia 14
Diarrhoea 12
Seizure NOS 12
Elevated alanine aminotransferase (ALT) 12
Elevated liver enzymes 11
Death 10
Elevated serum alkaline phosphatase (SAP) 10
Death by euthanasia 10
Other abnormal test result NOS 9
Behavioural disorder NOS 9

Outcome Breakdown

Ongoing
53 (45.3%)
Outcome Unknown
29 (24.8%)
Recovered/Normal
14 (12.0%)
Died
11 (9.4%)
Euthanized
10 (8.5%)

Glucosamine Hcl, Chondroitin Sulfate & Manganese: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Glucosamine Hcl, Chondroitin Sulfate & Manganese, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (17.9% here), distinct from the volume row.

What to do with this drug

  • Compare Glucosamine Hcl, Chondroitin Sulfate & Manganese's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glucosamine Hcl, Chondroitin Sulfate & Manganese (#719 of 2,679 by report volume); death-coded 17.9%. PlainBreed drug row · death-coded report count stamp 21 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →