Drug profile

The FDA adverse-event record for Glucosamine Hcl, Chondroitin Sulfate & Manganese

117 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine Hcl, Chondroitin Sulfate & Manganese. See the species affected, top reactions, and outcomes below.

117
adverse-event reports
17.9%
death-coded share
Dog
most-reported species
32
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
117
Total Reports
21
Deaths Reported
17.9%
Death Rate

Active Ingredients

Glucosamine Hcl, Chondroitin Sulfate & Manganese

Administration Routes

OralUnknown

Species Affected

Dog 93
Cat 22
Horse 2

Most Affected Breeds

Retriever - Labrador 21
Domestic Shorthair 15
Retriever - Golden 6
Shepherd Dog - German 5
Boxer (German Boxer) 4
Terrier - Bull - American Pit 4
Shepherd Dog - Australian 4
Shepherd (unspecified) 3
Shih Tzu 2
Great Pyrenees 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 32
Vomiting 19
Anorexia 14
Diarrhoea 12
Seizure NOS 12
Elevated alanine aminotransferase (ALT) 12
Elevated liver enzymes 11
Death 10
Elevated serum alkaline phosphatase (SAP) 10
Death by euthanasia 10
Other abnormal test result NOS 9
Behavioural disorder NOS 9

Outcome Breakdown

Ongoing
53 (45.3%)
Outcome Unknown
29 (24.8%)
Recovered/Normal
14 (12.0%)
Died
11 (9.4%)
Euthanized
10 (8.5%)

Glucosamine Hcl, Chondroitin Sulfate & Manganese Adverse Event Insights

117 reports name Glucosamine Hcl, Chondroitin Sulfate & Manganese; 21 recorded a death outcome (17.9% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine Hcl, Chondroitin Sulfate & Manganese. Administration routes: Oral, Unknown.

By species: Dog (93 reports), Cat (22 reports), Horse (2 reports). By breed: Retriever - Labrador (21), Domestic Shorthair (15), Retriever - Golden (6).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (32), Vomiting (19), Anorexia (14), Diarrhoea (12). Outcome, 117 coded reports: Ongoing leads at 45.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.