Drug profile

The FDA adverse-event record for Glucosamine, Chondroitin, Unsaponifiables

303 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine, Chondroitin, Unsaponifiables. See the species affected, top reactions, and outcomes below.

303
adverse-event reports
11.2%
death-coded share
Dog
most-reported species
71
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
303
Total Reports
34
Deaths Reported
11.2%
Death Rate

Active Ingredients

Glucosamine, Chondroitin, Unsaponifiables

Administration Routes

OralUnknown

Species Affected

Dog 297
Cat 6

Most Affected Breeds

Retriever - Labrador 77
Retriever - Golden 17
Shepherd Dog - German 12
Shepherd (unspecified) 8
Terrier (unspecified) 7
Shepherd Dog - Australian 6
Terrier - Yorkshire 6
Pug 6
Poodle - Standard 5
Mixed (Dog) 5

Most Reported Reactions

Vomiting 71
Lethargy (see also Central nervous system depression in 'Neurological') 54
Elevated alanine aminotransferase (ALT) 51
Elevated serum alkaline phosphatase (SAP) 44
Diarrhoea 35
Anorexia 35
Other abnormal test result NOS 35
Elevated total bilirubin 33
Elevated liver enzymes 28
Weight loss 25
Not eating 24
Decreased appetite 23

Outcome Breakdown

Ongoing
167 (54.9%)
Recovered/Normal
67 (22.0%)
Outcome Unknown
36 (11.8%)
Euthanized
21 (6.9%)
Died
13 (4.3%)

Glucosamine, Chondroitin, Unsaponifiables Adverse Event Insights

303 reports name Glucosamine, Chondroitin, Unsaponifiables; 34 recorded a death outcome (11.2% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine, Chondroitin, Unsaponifiables. Administration routes: Oral, Unknown.

By species: Dog (297 reports), Cat (6 reports). By breed: Retriever - Labrador (77), Retriever - Golden (17), Shepherd Dog - German (12).

Leading clinical signs: Vomiting (71), Lethargy (see also Central nervous system depression in 'Neurological') (54), Elevated alanine aminotransferase (ALT) (51), Elevated serum alkaline phosphatase (SAP) (44). Outcome, 304 coded reports: Ongoing leads at 54.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.