Drug profile

The FDA adverse-event record for Glucosamine, Chondroitin Sulfate

58 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine, Chondroitin Sulfate. Species, reactions, and outcomes follow.

#1029 of 2,679
by report volume (all drugs)
58
adverse-event reports
29.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine, Chondroitin Sulfate ranks #1025 of 2679 by total reports (58) and #126 of 1130 by death-coded share (29.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1025
This drug, reports of 2679
#126
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glucosamine, Chondroitin Sulfate has 58 reports now versus 54 in that prior snapshot: 4 more (7.4%).

Report change
+4
Death-coded reports
+2
Death-coded share
+1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glucosamine, Chondroitin Sulfate changes

Signature read: Glucosamine, Chondroitin Sulfate's 29.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
58
Total Reports
17
Deaths Reported
29.3%
Death-coded share of reports

Active Ingredients

Glucosamine, Chondroitin Sulfate

Administration Routes

OralUnknown

Species Affected

Dog 41
Cat 17

Most Affected Breeds

Retriever - Labrador 11
Domestic Shorthair 7
Shepherd Dog - German 4
Terrier (unspecified) 3
Domestic Longhair 2
Cat (other) 2
Domestic Mediumhair 2
Terrier - Bull - American Pit 2
Retriever - Golden 2
Retriever - Chesapeake Bay 2

Most Reported Reactions

Diarrhoea 12
Vomiting 12
Weight loss 12
Not eating 10
Death by euthanasia 9
Death 8
Lethargy (see also Central nervous system depression in Neurological) 8
Panting 7
Weakness 7
Lack of efficacy - NOS 6
Behavioural disorder NOS 6
Elevated alanine aminotransferase (ALT) 5

Outcome Breakdown

Ongoing
25 (43.1%)
Recovered/Normal
13 (22.4%)
Euthanized
9 (15.5%)
Died
8 (13.8%)
Outcome Unknown
3 (5.2%)

Glucosamine, Chondroitin Sulfate: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Glucosamine, Chondroitin Sulfate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (58 here).

Similar death-coded share

Nearest other drugs by death-coded share (29.3% here), distinct from the volume row.

What to do with this drug

  • Compare Glucosamine, Chondroitin Sulfate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glucosamine, Chondroitin Sulfate (#1029 of 2,679 by report volume); death-coded 29.3%. PlainBreed drug row · death-coded share stamp 29.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →