Drug profile

The FDA adverse-event record for Glucosamine + Chondroitin + Msm

22 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine + Chondroitin + Msm. See the species affected, top reactions, and outcomes below.

22
adverse-event reports
9.1%
death-coded share
Dog
most-reported species
8
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
22
Total Reports
2
Deaths Reported
9.1%
Death Rate

Active Ingredients

Glucosamine + Chondroitin + Msm

Administration Routes

OralUnknown

Species Affected

Dog 21
Cat 1

Most Affected Breeds

Retriever - Labrador 7
Retriever - Golden 4
Pointing Dog - German Short-haired 2
Rottweiler 1
Boxer (German Boxer) 1
Collie (unspecified) 1
Dachshund (unspecified) 1
Pit Bull 1
Collie - Border 1
Terrier - Boston 1

Most Reported Reactions

Vomiting 8
Arthritis 5
Gastritis 3
Not eating 3
Lack of efficacy (endoparasite) - tapeworm 3
Lack of efficacy - NOS 2
Pain NOS 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Diarrhoea 2
Behavioural disorder NOS 2
Fluid in abdomen NOS 2
Elevated lactate 2

Outcome Breakdown

Outcome Unknown
10 (45.5%)
Ongoing
5 (22.7%)
Recovered/Normal
4 (18.2%)
Euthanized
1 (4.5%)
Recovered with Sequela
1 (4.5%)
Died
1 (4.5%)

Glucosamine + Chondroitin + Msm Adverse Event Insights

22 reports name Glucosamine + Chondroitin + Msm; 2 recorded a death outcome (9.1% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine + Chondroitin + Msm. Administration routes: Oral, Unknown.

By species: Dog (21 reports), Cat (1 reports). By breed: Retriever - Labrador (7), Retriever - Golden (4), Pointing Dog - German Short-haired (2).

Leading clinical signs: Vomiting (8), Arthritis (5), Gastritis (3), Not eating (3). Outcome, 22 coded reports: Outcome Unknown leads at 45.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.