Drug profile

The FDA adverse-event record for Glipizide

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glipizide. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
15.0%
death-coded share
Cat
most-reported species
5
Ketosis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
3
Deaths Reported
15.0%
Death Rate

Active Ingredients

Glipizide

Administration Routes

UnknownOralTransdermal

Species Affected

Cat 12
Human 7
Dog 1

Most Affected Breeds

Domestic Shorthair 7
Unknown 7
Siamese 2
Domestic Mediumhair 2
Crossbred Canine/dog 1
Ragdoll 1

Most Reported Reactions

Ketosis 5
Lethargy (see also Central nervous system depression in Neurological) 4
Vomiting 3
Decreased appetite 3
Accidental exposure 3
Behavioural disorder NOS 2
Weight loss 2
Elevated alanine aminotransferase (ALT) 2
Rash 2
Anxiety 2
Seizure NOS 2
Death by euthanasia 2

Outcome Breakdown

Ongoing
7 (35.0%)
Outcome Unknown
6 (30.0%)
Recovered/Normal
3 (15.0%)
Euthanized
2 (10.0%)
Recovered with Sequela
1 (5.0%)
Died
1 (5.0%)

Glipizide Adverse Event Insights

20 reports name Glipizide; 3 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). Active ingredient: Glipizide. Administration routes: Unknown, Oral, Transdermal.

By species: Cat (12 reports), Human (7 reports), Dog (1 reports). By breed: Domestic Shorthair (7), Unknown (7), Siamese (2).

Leading clinical signs: Ketosis (5), Lethargy (see also Central nervous system depression in Neurological) (4), Vomiting (3), Decreased appetite (3). Outcome, 20 coded reports: Ongoing leads at 35.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.