Drug profile

The FDA adverse-event record for Genta/Betamet/Clotrim Ear Oint

511 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Genta/Betamet/Clotrim Ear Oint. See the species affected, top reactions, and outcomes below.

511
adverse-event reports
2.0%
death-coded share
Dog
most-reported species
225
Deafness - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
511
Total Reports
10
Deaths Reported
2.0%
Death Rate

Active Ingredients

Genta/Betamet/Clotrim Ear Oint

Administration Routes

Auricular (Otic)UnknownTopicalOralOphthalmicOtherSubcutaneous

Species Affected

Dog 403
Unknown 94
Cat 14

Most Affected Breeds

Unknown 96
Crossbred Canine/dog 79
Retriever - Labrador 43
Retriever - Golden 22
Terrier - Yorkshire 17
Shepherd Dog - German 17
Dog (unknown) 17
Boxer (German Boxer) 15
Pug 13
Chihuahua 13

Most Reported Reactions

Deafness 225
Partial deafness 47
Drug administration duration too long 41
Applicator, Abnormal 27
Product problem 25
Product Defect, General 22
Underdose 22
Drug dose administration interval too long 21
Containers, Leaking 19
Drug dose prescribing error 19
Lethargy (see also Central nervous system depression in 'Neurological') 18
Lack of efficacy - NOS 17

Outcome Breakdown

Recovered with Sequela
189 (45.3%)
Recovered/Normal
94 (22.5%)
Ongoing
71 (17.0%)
Outcome Unknown
53 (12.7%)
Euthanized
7 (1.7%)
Died
3 (0.7%)

Genta/Betamet/Clotrim Ear Oint Adverse Event Insights

511 reports name Genta/Betamet/Clotrim Ear Oint; 10 recorded a death outcome (2.0% of reported events, not a population-level mortality rate). Active ingredient: Genta/Betamet/Clotrim Ear Oint. Administration routes: Auricular (Otic), Unknown, Topical, Oral.

By species: Dog (403 reports), Unknown (94 reports), Cat (14 reports). By breed: Unknown (96), Crossbred Canine/dog (79), Retriever - Labrador (43).

Leading clinical signs: Deafness (225), Partial deafness (47), Drug administration duration too long (41), Applicator, Abnormal (27). Outcome, 417 coded reports: Recovered with Sequela leads at 45.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.