Drug profile

The FDA adverse-event record for Forti-Flora

24 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Forti-Flora. Species, reactions, and outcomes follow.

#1628 of 2,679
by report volume (all drugs)
24
adverse-event reports
16.7%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Forti-Flora ranks #1609 of 2679 by total reports (24). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1609
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Forti-Flora has 24 reports now versus 24 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Forti-Flora changes

Signature read: Forti-Flora's 16.7% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
24
Total Reports
4
Deaths Reported
16.7%
Death-coded share of reports

Active Ingredients

Forti-Flora

Administration Routes

OralUnknown

Species Affected

Dog 17
Cat 7

Most Affected Breeds

Domestic Shorthair 3
Poodle - Toy 3
Retriever - Labrador 3
Terrier - Yorkshire 2
Poodle (unspecified) 2
Cat (other) 2
Chihuahua 1
Boxer (German Boxer) 1
Beagle 1
Bulldog - American 1

Most Reported Reactions

Diarrhoea 5
Emesis (multiple) 4
Abnormal radiograph finding 4
Vomiting 4
Weight loss 3
Pain NOS 3
Limb weakness 3
Elevated blood urea nitrogen (BUN) 2
Lameness 2
Loose stool 2
Death 2
Hind limb ataxia 2

Outcome Breakdown

Ongoing
16 (66.7%)
Died
2 (8.3%)
Recovered/Normal
2 (8.3%)
Outcome Unknown
2 (8.3%)
Euthanized
2 (8.3%)

Forti-Flora Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Forti-Flora (#1628 of 2,679 by report volume); death-coded 16.7%. PlainBreed drug row · death-coded share stamp 16.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →