Drug profile

The FDA adverse-event record for Fluticasone

69 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Fluticasone. Species, reactions, and outcomes follow.

#940 of 2,679
by report volume (all drugs)
69
adverse-event reports
8.7%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Fluticasone ranks #937 of 2679 by total reports (69) and #608 of 1130 by death-coded share (8.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#937
This drug, reports of 2679
#608
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fluticasone has 69 reports now versus 62 in that prior snapshot: 7 more (11.3%).

Report change
+7
Death-coded reports
+0
Death-coded share
−1.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fluticasone changes

Signature read: report volume at 69 is the most distinctive stamp on Fluticasone's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
69
Total Reports
6
Deaths Reported
8.7%
Death-coded share of reports

Active Ingredients

Fluticasone

Administration Routes

UnknownRespiratory (Inhalation)NasalOtherOral

Species Affected

Cat 39
Dog 20
Human 8
Other 1
Horse 1

Most Affected Breeds

Domestic Shorthair 27
Unknown 9
Boxer (German Boxer) 4
Ocicat 3
Retriever - Labrador 3
Chihuahua 2
Spaniel - Cocker American 2
Terrier - Jack Russell 1
Terrier - Bull - American Pit 1
Terrier - Yorkshire 1

Most Reported Reactions

Diarrhoea 12
Lack of efficacy - NOS 9
Abnormal radiograph finding 9
Vomiting 8
Elevated blood urea nitrogen (BUN) 8
Lethargy (see also Central nervous system depression in Neurological) 7
Inappetence 7
Anaphylaxis 5
Other abnormal test result NOS 5
Proteinuria 5
Pale mucous membrane 4
Death by euthanasia 4

Outcome Breakdown

Ongoing
24 (35.3%)
Outcome Unknown
20 (29.4%)
Recovered/Normal
17 (25.0%)
Euthanized
4 (5.9%)
Died
2 (2.9%)
Recovered with Sequela
1 (1.5%)

Fluticasone Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Fluticasone, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (8.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fluticasone (#940 of 2,679 by report volume); death-coded 8.7%. PlainBreed drug row · report volume stamp 69 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →