Drug profile

The FDA adverse-event record for Flunixin Meglumine

437 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Flunixin Meglumine. See the species affected, top reactions, and outcomes below.

437
adverse-event reports
29.5%
death-coded share
Horse
most-reported species
87
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
437
Total Reports
129
Deaths Reported
29.5%
Death Rate

Active Ingredients

Flunixin Meglumine

Administration Routes

UnknownIntravenousIntramuscularSubcutaneousOralParenteralOtherIntra-ArterialOphthalmic

Species Affected

Horse 169
Unknown 114
Cattle 104
Dog 15
Pig 10
Human 9
Sheep 5
Goat 3
Cat 3
Donkey 2

Most Affected Breeds

Unknown 142
Quarter Horse 52
Holstein-Friesian also known as Holstein 32
Horse (unknown) 18
Crossbred Bovine/Cattle 16
Cattle (unknown) 16
Thoroughbred 14
Mixed (Cattle) 11
Aberdeen Angus 11
Warmblood (unspecified) 11

Most Reported Reactions

Death 87
Death by euthanasia 25
Colic 23
Fever 21
Anaphylaxis 21
Lethargy (see also Central nervous system depression in 'Neurological') 21
Injection site swelling 20
Lack of efficacy - NOS 20
Elevated creatinine 20
Solution, Abnormal 19
Elevated blood urea nitrogen (BUN) 19
Contamination NOS 17

Outcome Breakdown

Died
108 (36.4%)
Recovered/Normal
86 (29.0%)
Outcome Unknown
53 (17.8%)
Euthanized
26 (8.8%)
Ongoing
19 (6.4%)
Recovered with Sequela
5 (1.7%)

Flunixin Meglumine Adverse Event Insights

437 reports name Flunixin Meglumine; 129 recorded a death outcome (29.5% of reported events, not a population-level mortality rate). Active ingredient: Flunixin Meglumine. Administration routes: Unknown, Intravenous, Intramuscular, Subcutaneous.

By species: Horse (169 reports), Unknown (114 reports), Cattle (104 reports). By breed: Unknown (142), Quarter Horse (52), Holstein-Friesian also known as Holstein (32).

Leading clinical signs: Death (87), Death by euthanasia (25), Colic (23), Fever (21). Outcome, 297 coded reports: Died leads at 36.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.