Drug profile

The FDA adverse-event record for Flunixin Meglumine

463 FDA reports name Flunixin Meglumine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#320 of 2,679
by report volume (all drugs)
463
adverse-event reports
29.4%
death-coded share
Horse
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Flunixin Meglumine ranks #320 of 2679 by total reports (463) and #125 of 1130 by death-coded share (29.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#320
This drug, reports of 2679
#125
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Flunixin Meglumine has 463 reports now versus 454 in that prior snapshot: 9 more (2.0%).

Report change
+9
Death-coded reports
+3
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Flunixin Meglumine changes

Signature read: death-coded report count at 136 is the most distinctive stamp on Flunixin Meglumine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
463
Total Reports
136
Deaths Reported
29.4%
Death-coded share of reports

Active Ingredients

Flunixin Meglumine

Administration Routes

UnknownIntravenousIntramuscularSubcutaneousOralParenteralOtherIntra-ArterialOphthalmic

Species Affected

Horse 181
Unknown 123
Cattle 108
Dog 15
Pig 10
Human 9
Sheep 5
Goat 4
Cat 3
Donkey 2

Most Affected Breeds

Unknown 151
Quarter Horse 55
Holstein-Friesian also known as Holstein 32
Horse (unknown) 20
Cattle (unknown) 17
Crossbred Bovine/Cattle 16
Thoroughbred 15
Aberdeen Angus 12
Warmblood (unspecified) 12
Mixed (Cattle) 11

Most Reported Reactions

Death 91
Death by euthanasia 27
Colic 24
Fever 23
Diarrhoea 22
Injection site swelling 21
Solution, Abnormal 21
Anaphylaxis 21
Lethargy (see also Central nervous system depression in 'Neurological') 21
Appearance, Abnormal 21
Lack of efficacy - NOS 21
Elevated blood urea nitrogen (BUN) 21

Outcome Breakdown

Died
113 (35.9%)
Recovered/Normal
96 (30.5%)
Outcome Unknown
52 (16.5%)
Euthanized
28 (8.9%)
Ongoing
21 (6.7%)
Recovered with Sequela
5 (1.6%)

Flunixin Meglumine: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Flunixin Meglumine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (463 here).

Similar death-coded share

Nearest other drugs by death-coded share (29.4% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Flunixin Meglumine (#320 of 2,679 by report volume); death-coded 29.4%. PlainBreed drug row · death-coded report count stamp 136 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →