Drug profile

The FDA adverse-event record for Flumethrin + Imidacloprid

350 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Flumethrin + Imidacloprid. See the species affected, top reactions, and outcomes below.

350
adverse-event reports
1.7%
death-coded share
Dog
most-reported species
116
Lack of efficacy (ectoparasite) - flea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
350
Total Reports
6
Deaths Reported
1.7%
Death Rate

Active Ingredients

FlumethrinFlumethrin + ImidaclopridImidacloprid

Administration Routes

TopicalCutaneousUnknownOtherTransdermal

Species Affected

Dog 306
Cat 44

Most Affected Breeds

Retriever - Labrador 38
Crossbred Canine/dog 32
Dog (unknown) 20
Retriever - Golden 18
Terrier - Yorkshire 15
Domestic Shorthair 15
Cat (unknown) 14
Shepherd Dog - German 13
Chihuahua 12
Shih Tzu 10

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 116
Pruritus 92
Vomiting 38
Lethargy (see also Central nervous system depression in 'Neurological') 34
Behavioural disorder NOS 25
Lack of efficacy (flea) 24
Other abnormal test result NOS 20
Diarrhoea 15
Emesis 14
INEFFECTIVE, HOOKS 13
Lack of efficacy (endoparasite) - heartworm 13
Seizure NOS 12

Outcome Breakdown

Outcome Unknown
209 (59.7%)
Ongoing
78 (22.3%)
Recovered/Normal
53 (15.1%)
Recovered with Sequela
4 (1.1%)
Died
4 (1.1%)
Euthanized
2 (0.6%)

Flumethrin + Imidacloprid Adverse Event Insights

350 reports name Flumethrin + Imidacloprid; 6 recorded a death outcome (1.7% of reported events, not a population-level mortality rate). Active ingredients: Flumethrin, Flumethrin + Imidacloprid, Imidacloprid. Administration routes: Topical, Cutaneous, Unknown, Other.

By species: Dog (306 reports), Cat (44 reports). By breed: Retriever - Labrador (38), Crossbred Canine/dog (32), Dog (unknown) (20).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (116), Pruritus (92), Vomiting (38), Lethargy (see also Central nervous system depression in 'Neurological') (34). Outcome, 350 coded reports: Outcome Unknown leads at 59.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.