Drug profile

The FDA adverse-event record for Florfenicol, Flunixin

147 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Florfenicol, Flunixin. See the species affected, top reactions, and outcomes below.

147
adverse-event reports
71.4%
death-coded share
Cattle
most-reported species
66
Lack of efficacy (bacteria) - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
147
Total Reports
105
Deaths Reported
71.4%
Death Rate

Active Ingredients

Florfenicol, Flunixin

Administration Routes

SubcutaneousUnknownTopicalOphthalmicIntramuscular

Species Affected

Cattle 116
Human 15
Unknown 12
Goat 2
Sheep 2

Most Affected Breeds

Holstein-Friesian also known as Holstein 62
Unknown 27
Crossbred Bovine/Cattle 24
Cattle (unknown) 19
Aberdeen Angus 7
Sheep (unknown) 2
Pygmy 1
Jersey 1
Goat (unknown) 1
Mixed (Cattle) 1

Most Reported Reactions

Lack of efficacy (bacteria) - NOS 66
Death 59
DEATH-TREATMENT FAILURE 42
CULTURE/TITER DATA ABNORMAL 39
PR-LUNG(S), LESION(S) 31
Unclassifiable adverse event 23
PR-GI, LESION(S) 16
Accidental exposure 14
PR-LIVER, LESION(S) 14
PR-SPLEEN, LESION(S) 14
PR-THYMUS, LESION(S) 8
PR-KIDNEY(S), LESION(S) 8

Outcome Breakdown

Died
105 (97.2%)
Outcome Unknown
1 (0.9%)
Ongoing
1 (0.9%)
Recovered/Normal
1 (0.9%)

Florfenicol, Flunixin Adverse Event Insights

147 reports name Florfenicol, Flunixin; 105 recorded a death outcome (71.4% of reported events, not a population-level mortality rate). Active ingredient: Florfenicol, Flunixin. Administration routes: Subcutaneous, Unknown, Topical, Ophthalmic.

By species: Cattle (116 reports), Human (15 reports), Unknown (12 reports). By breed: Holstein-Friesian also known as Holstein (62), Unknown (27), Crossbred Bovine/Cattle (24).

Leading clinical signs: Lack of efficacy (bacteria) - NOS (66), Death (59), DEATH-TREATMENT FAILURE (42), CULTURE/TITER DATA ABNORMAL (39). Outcome, 108 coded reports: Died leads at 97.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.