Drug profile

The FDA adverse-event record for Florfenicol, Flunixin

147 FDA reports name Florfenicol, Flunixin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#636 of 2,679
by report volume (all drugs)
147
adverse-event reports
71.4%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Florfenicol, Flunixin ranks #635 of 2679 by total reports (147) and #32 of 1130 by death-coded share (71.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#635
This drug, reports of 2679
#32
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Florfenicol, Flunixin has 147 reports now versus 147 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Florfenicol, Flunixin changes

Signature read: Florfenicol, Flunixin's 71.4% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
147
Total Reports
105
Deaths Reported
71.4%
Death-coded share of reports

Active Ingredients

Florfenicol, Flunixin

Administration Routes

SubcutaneousUnknownTopicalOphthalmicIntramuscular

Species Affected

Cattle 116
Human 15
Unknown 12
Goat 2
Sheep 2

Most Affected Breeds

Holstein-Friesian also known as Holstein 62
Unknown 27
Crossbred Bovine/Cattle 24
Cattle (unknown) 19
Aberdeen Angus 7
Sheep (unknown) 2
Pygmy 1
Jersey 1
Goat (unknown) 1
Mixed (Cattle) 1

Most Reported Reactions

Lack of efficacy (bacteria) - NOS 66
Death 59
DEATH-TREATMENT FAILURE 42
CULTURE/TITER DATA ABNORMAL 39
PR-LUNG(S), LESION(S) 31
Unclassifiable adverse event 23
PR-GI, LESION(S) 16
Accidental exposure 14
PR-LIVER, LESION(S) 14
PR-SPLEEN, LESION(S) 14
PR-THYMUS, LESION(S) 8
PR-KIDNEY(S), LESION(S) 8

Outcome Breakdown

Died
105 (97.2%)
Ongoing
1 (0.9%)
Outcome Unknown
1 (0.9%)
Recovered/Normal
1 (0.9%)

Florfenicol, Flunixin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Florfenicol, Flunixin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (71.4% here), distinct from the volume row.

Zilpaterol 72.1% Plasma 72.9% Narasin 73.2% Narasin + Nicarbazin 68.9%

What to do with this drug

  • Compare Florfenicol, Flunixin's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Florfenicol, Flunixin (#636 of 2,679 by report volume); death-coded 71.4%. PlainBreed drug row · death-coded share stamp 71.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →