Drug profile

The FDA adverse-event record for Firocoxib 227 Mg Chewable

999 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Firocoxib 227 Mg Chewable. See the species affected, top reactions, and outcomes below.

999
adverse-event reports
16.6%
death-coded share
Dog
most-reported species
294
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
999
Total Reports
166
Deaths Reported
16.6%
Death Rate

Active Ingredients

Firocoxib 227 Mg Chewable

Administration Routes

OralUnknownTopical

Species Affected

Dog 832
Unknown 138
Horse 17
Cat 8
Human 4

Most Affected Breeds

Retriever - Labrador 174
Unknown 148
Crossbred Canine/dog 81
Dog (other) 70
Shepherd Dog - German 61
Retriever - Golden 53
Dog (unknown) 46
Boxer (German Boxer) 45
Rottweiler 27
Mastiff 19

Most Reported Reactions

Vomiting 294
Other abnormal test result NOS 244
Lethargy (see also Central nervous system depression in 'Neurological') 146
Elevated blood urea nitrogen (BUN) 145
Elevated creatinine 117
Elevated serum alkaline phosphatase (SAP) 92
Death 90
Anorexia 83
Diarrhoea 78
Elevated alanine aminotransferase (ALT) 74
Death by euthanasia 73
Not eating 62

Outcome Breakdown

Outcome Unknown
423 (49.1%)
Recovered/Normal
162 (18.8%)
Ongoing
105 (12.2%)
Died
94 (10.9%)
Euthanized
72 (8.4%)
Recovered with Sequela
6 (0.7%)

Firocoxib 227 Mg Chewable Adverse Event Insights

999 reports name Firocoxib 227 Mg Chewable; 166 recorded a death outcome (16.6% of reported events, not a population-level mortality rate). Active ingredient: Firocoxib 227 Mg Chewable. Administration routes: Oral, Unknown, Topical.

By species: Dog (832 reports), Unknown (138 reports), Horse (17 reports). By breed: Retriever - Labrador (174), Unknown (148), Crossbred Canine/dog (81).

Leading clinical signs: Vomiting (294), Other abnormal test result NOS (244), Lethargy (see also Central nervous system depression in 'Neurological') (146), Elevated blood urea nitrogen (BUN) (145). Outcome, 862 coded reports: Outcome Unknown leads at 49.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.