Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On

21 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

480.0%

Death Rate

Active Ingredients

Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On

Administration Routes

OtherUnknown

Species Affected

Dog 21

Most Affected Breeds

Retriever - Golden 4

Shepherd Dog - Australian 3

Collie - Border 2

Collie (unspecified) 1

Sheepdog - Shetland 1

Bulldog - French 1

Mixed (Dog) 1

Chihuahua 1

Retriever - Labrador 1

Pointing Dog - Italian Wire-haired 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 13

Vomiting 5

Other abnormal test result NOS 4

Application site irritation 3

Elevated alanine aminotransferase (ALT) 3

Pemphigus foliaceus 2

Walking difficulty 2

Flaking skin 2

Neutrophilia 2

Polyuria 2

Dermatitis 2

Erythema (for urticaria see Immune SOC) 2

Outcome Breakdown

Recovered/Normal

13 (61.9%)

Outcome Unknown

4 (19.0%)

Recovered with Sequela

2 (9.5%)

Ongoing

1 (4.8%)

Euthanized

1 (4.8%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.