Fipronil 9.8% / S-Methoprene 8.8% / Pyriproxyfen 0.25% Topical Solution
117 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
117
Total Reports
1
Deaths Reported
90.0%
Death Rate
Active Ingredients
Fipronil 9.8% / S-Methoprene 8.8% / Pyriproxyfen 0.25% Topical Solution
Administration Routes
OtherUnknownOral
Species Affected
Dog 117
Most Affected Breeds
Dog (unknown) 11
Retriever - Labrador 8
Retriever - Golden 7
Crossbred Canine/dog 7
Terrier - Yorkshire 6
Bichon Frise 5
Maltese 4
Beagle 4
Dog (other) 4
Shih Tzu 4
Most Reported Reactions
Vomiting 33
Lethargy (see also Central nervous system depression in 'Neurological') 17
Diarrhoea 14
Seizure NOS 9
Lack of efficacy (flea) 9
Behavioural disorder NOS 8
Itching 8
Anorexia 7
Application site reddening 7
Appetite loss 6
Application site hair change 5
Hyperactivity 5
Outcome Breakdown
Recovered/Normal
58 (49.6%)
Outcome Unknown
56 (47.9%)
Ongoing
2 (1.7%)
Died
1 (0.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.