Drug profile

The FDA adverse-event record for Feline Combination Vaccine

12 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Feline Combination Vaccine. See the species affected, top reactions, and outcomes below.

12
adverse-event reports
16.7%
death-coded share
Cat
most-reported species
4
Ataxia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
12
Total Reports
2
Deaths Reported
16.7%
Death Rate

Active Ingredients

Feline Combination Vaccine

Administration Routes

SubcutaneousUnknown

Species Affected

Cat 12

Most Affected Breeds

Domestic Shorthair 8
Domestic Mediumhair 3
Cat (unknown) 1

Most Reported Reactions

Ataxia 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Application site alopecia 2
Application site erythema 2
Application site irritation 2
Hind limb paresis 2
Diarrhoea 1
Decreased appetite 1
Application site pyoderma 1
Application site pruritus 1
Application site twitching 1
Twitching 1

Outcome Breakdown

Outcome Unknown
7 (58.3%)
Recovered/Normal
3 (25.0%)
Euthanized
1 (8.3%)
Died
1 (8.3%)

Feline Combination Vaccine Adverse Event Insights

12 reports name Feline Combination Vaccine; 2 recorded a death outcome (16.7% of reported events, not a population-level mortality rate). Active ingredient: Feline Combination Vaccine. Administration routes: Subcutaneous, Unknown.

By species: Cat (12 reports). By breed: Domestic Shorthair (8), Domestic Mediumhair (3), Cat (unknown) (1).

Leading clinical signs: Ataxia (4), Lethargy (see also Central nervous system depression in 'Neurological') (3), Application site alopecia (2), Application site erythema (2). Outcome, 12 coded reports: Outcome Unknown leads at 58.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.