Drug profile

The FDA adverse-event record for Eye Medication

72 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eye Medication. Species, reactions, and outcomes follow.

#926 of 2,679
by report volume (all drugs)
72
adverse-event reports
16.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Eye Medication ranks #922 of 2679 by total reports (72) and #313 of 1130 by death-coded share (16.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#922
This drug, reports of 2679
#313
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eye Medication has 72 reports now versus 72 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eye Medication changes

Signature read: death-coded report count at 12 is the most distinctive stamp on Eye Medication's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
72
Total Reports
12
Deaths Reported
16.7%
Death-coded share of reports

Active Ingredients

Eye Medication

Administration Routes

OphthalmicUnknownIntraocularAuricular (Otic)

Species Affected

Dog 58
Cat 14

Most Affected Breeds

Shih Tzu 9
Domestic Shorthair 7
Maltese 5
Bulldog 3
Spaniel - Cocker American 2
Chihuahua 2
Terrier - Yorkshire 2
Terrier - Rat 2
Schnauzer (unspecified) 2
Retriever - Golden 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 17
Weight loss 11
Other abnormal test result NOS 9
Elevated serum alkaline phosphatase (SAP) 9
Anorexia 9
Lack of efficacy - NOS 8
Vomiting 8
Death by euthanasia 6
Emesis 6
Corneal ulcer 6
Abnormal ultrasound finding 6
Elevated alanine aminotransferase (ALT) 6

Outcome Breakdown

Ongoing
35 (48.6%)
Outcome Unknown
15 (20.8%)
Recovered/Normal
9 (12.5%)
Euthanized
6 (8.3%)
Died
6 (8.3%)
Recovered with Sequela
1 (1.4%)

Eye Medication Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Eye Medication, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (72 here).

Similar death-coded share

Nearest other drugs by death-coded share (16.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eye Medication (#926 of 2,679 by report volume); death-coded 16.7%. PlainBreed drug row · death-coded report count stamp 12 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →