Drug profile

The FDA adverse-event record for Estrogen

22 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Estrogen. See the species affected, top reactions, and outcomes below.

22
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
5
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
22
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Estrogen

Administration Routes

UnknownOral

Species Affected

Dog 20
Human 2

Most Affected Breeds

Retriever - Labrador 4
Akita 3
Unknown 2
Crossbred Canine/dog 2
Chihuahua 2
Siberian Husky 2
Chow Chow 2
Shar Pei 1
Pointing Dog - German Short-haired 1
Spaniel (unspecified) 1

Most Reported Reactions

Emesis 5
Anorexia 5
Decreased appetite 3
Hyperkalaemia 3
Elevated blood urea nitrogen (BUN) 3
Cough 3
Lethargy (see also Central nervous system depression in 'Neurological') 2
Other abnormal test result NOS 2
Thrombocytosis 2
Lack of efficacy - NOS 2
Weakness 2
Hypocortisolaemia 2

Outcome Breakdown

Ongoing
11 (50.0%)
Recovered/Normal
6 (27.3%)
Outcome Unknown
5 (22.7%)

Estrogen Adverse Event Insights

22 reports name Estrogen; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Estrogen. Administration routes: Unknown, Oral.

By species: Dog (20 reports), Human (2 reports). By breed: Retriever - Labrador (4), Akita (3), Unknown (2).

Leading clinical signs: Emesis (5), Anorexia (5), Decreased appetite (3), Hyperkalaemia (3). Outcome, 22 coded reports: Ongoing leads at 50.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.