Estriol Tablets
1,278 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,278
Total Reports
82
Deaths Reported
640.0%
Death Rate
Active Ingredients
Estriol Tablets
Administration Routes
OralUnknownTopicalOther
Species Affected
Dog 1,249
Unknown 21
Human 6
Cat 2
Most Affected Breeds
Crossbred Canine/dog 276
Retriever - Labrador 68
Doberman Pinscher 60
Shepherd Dog - German 48
Terrier - Yorkshire 46
Dog (unknown) 35
Poodle - Miniature 34
Unknown 29
Terrier (unspecified) 26
Shepherd Dog - Australian 26
Most Reported Reactions
Lack of efficacy - NOS 389
Swollen vulva 331
Vaginal discharge 74
Death by euthanasia 74
Urinary incontinence 69
Genital tract licking 67
Lethargy (see also Central nervous system depression in 'Neurological') 62
Decreased appetite 57
Vaginal haemorrhage 56
Emesis (multiple) 51
Weight loss 50
Other abnormal test result NOS 49
Outcome Breakdown
Ongoing
750 (59.6%)
Recovered/Normal
218 (17.3%)
Outcome Unknown
182 (14.5%)
Euthanized
73 (5.8%)
Recovered with Sequela
27 (2.1%)
Died
9 (0.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.