Drug profile

The FDA adverse-event record for Estradiol + Progesterone

14 FDA reports name Estradiol + Progesterone, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2165 of 2,679
by report volume (all drugs)
14
adverse-event reports
57.1%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Estradiol + Progesterone ranks #2133 of 2679 by total reports (14). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2133
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Estradiol + Progesterone has 14 reports now versus 14 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Estradiol + Progesterone changes

Signature read: Estradiol + Progesterone's 57.1% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
14
Total Reports
8
Deaths Reported
57.1%
Death-coded share of reports

Active Ingredients

EstradiolProgesterone

Administration Routes

OtherUnknownSubcutaneous

Species Affected

Cattle 10
Unknown 4

Most Affected Breeds

Unknown 4
Cattle (unknown) 2
Mixed (Cattle) 2
Aberdeen Angus 2
Charolais 1
Hereford cattle 1
Crossbred Bovine/Cattle 1
Red Angus 1

Most Reported Reactions

Death 8
Anaphylaxis 3
NT - Abnormal necropsy finding NOS 3
Recumbency 3
Depression 2
Nasal discharge 2
Pyrexia 2
Weight loss 2
INEFFECTIVE, WEIGHT INC 2
Injection site haematoma 1
Injection site reaction NOS 1
Dyspnoea 1

Outcome Breakdown

Died
8 (66.7%)
Ongoing
2 (16.7%)
Outcome Unknown
2 (16.7%)

Estradiol + Progesterone: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Estradiol + Progesterone (#2165 of 2,679 by report volume); death-coded 57.1%. PlainBreed drug row · death-coded share stamp 57.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →