Estradiol + Progesterone
14 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 14 |
| Reports involving death | 8 |
| Case-fatality rate (reported events) | 5710.0% |
| Distinct species in reports | 2 |
| Distinct breeds in reports | 8 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 2 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Estradiol + Progesterone Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 14 adverse event reports referencing Estradiol + Progesterone, including 8 reports in which the animal died — a 5710.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredients on file: Estradiol, Progesterone. Reported administration routes include Other, Unknown, Subcutaneous. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Estradiol + Progesterone reports are Cattle (10 reports), Unknown (4 reports), with Cattle accounting for the largest share. Within those species, Unknown (4), Cattle (unknown) (2), Mixed (Cattle) (2) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Estradiol + Progesterone are Death (8), Anaphylaxis (3), NT - Abnormal necropsy finding NOS (3), Recumbency (3). Of the 12 reports with a coded outcome, Died is the leading category at 66.7%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Estradiol + Progesterone.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.