Drug profile

The FDA adverse-event record for Esafoxolaner,Eprinomectin,Praziquantel

Name: Esafoxolaner,Eprinomectin,Praziquantel - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

22 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Esafoxolaner,Eprinomectin,Praziquantel. Species, reactions, and outcomes follow.

#1695 of 2,679
by report volume (all drugs): 22
adverse-event reports: 4.5%
death-coded share: Cat
most-reported species

Compiled by PlainBreed

Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Esafoxolaner,Eprinomectin,Praziquantel ranks #1671 of 2679 by total reports (22). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1): 97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1): #1671
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Esafoxolaner,Eprinomectin,Praziquantel has 22 reports now versus 19 in that prior snapshot: 3 more (15.8%).

Report change: +3
Death-coded reports: +0
Death-coded share: −0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Esafoxolaner,Eprinomectin,Praziquantel changes

Signature read: death-coded report count at 1 is the most distinctive stamp on Esafoxolaner,Eprinomectin,Praziquantel's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

4.5%

Death-coded share of reports

Active Ingredients

Esafoxolaner,Eprinomectin,Praziquantel

Administration Routes

TopicalUnknownOralParenteral

Species Affected

Cat 19

Dog 3

Most Affected Breeds

Domestic Shorthair 13

Cat (unknown) 2

Domestic Longhair 2

Brittany 1

Retriever - Golden 1

Shih Tzu 1

Crossbred Feline/cat 1

Abyssinian cat 1

Most Reported Reactions

Ketosis 4

Other abnormal test result NOS 4

Weight loss 3

Lack of efficacy - NOS 3

Dilated pupils 3

Lack of efficacy (endoparasite) - tapeworm 3

Anorexia 2

Lack of efficacy (endoparasite) - heartworm 2

Seizure NOS 2

Not eating 2

Pyrexia 2

Behavioural disorder NOS 2

Outcome Breakdown

Ongoing

10 (45.5%)

Outcome Unknown

7 (31.8%)

Recovered/Normal

4 (18.2%)

Euthanized

1 (4.5%)

Esafoxolaner,Eprinomectin,Praziquantel: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Esafoxolaner,Eprinomectin,Praziquantel (#1695 of 2,679 by report volume); death-coded 4.5%. PlainBreed drug row · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →