Drug profile

The FDA adverse-event record for Eprinomectin 5% Injection

228 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eprinomectin 5% Injection. See the species affected, top reactions, and outcomes below.

228
adverse-event reports
12.3%
death-coded share
Cattle
most-reported species
38
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
228
Total Reports
28
Deaths Reported
12.3%
Death Rate

Active Ingredients

Eprinomectin 5% Injection

Administration Routes

UnknownSubcutaneousParenteralIntramuscularOtherTopicalOphthalmicCutaneousOral

Species Affected

Cattle 148
Human 39
Unknown 35
Goat 4
Dog 1
Alpaca 1

Most Affected Breeds

Unknown 76
Aberdeen Angus 48
Cattle (unknown) 24
Cattle (other) 22
Crossbred Bovine/Cattle 17
Brangus 8
Holstein-Friesian also known as Holstein 5
Hereford cattle 4
Jersey 4
Goat (unknown) 3

Most Reported Reactions

Lack of efficacy - NOS 38
Digestive tract disorder NOS 30
Lack of efficacy (endoparasite) - NOS 30
Death 26
Injection site lesion 24
Low weight gain 24
Injection site swelling 19
INEFFECTIVE, PARASITE(S) NOS 14
Uncoded sign 14
Unthrifty 12
Poor coat condition 11
Skin lesion NOS 10

Outcome Breakdown

Outcome Unknown
140 (70.4%)
Died
27 (13.6%)
Recovered/Normal
23 (11.6%)
Ongoing
7 (3.5%)
Euthanized
1 (0.5%)
Recovered with Sequela
1 (0.5%)

Eprinomectin 5% Injection Adverse Event Insights

228 reports name Eprinomectin 5% Injection; 28 recorded a death outcome (12.3% of reported events, not a population-level mortality rate). Active ingredient: Eprinomectin 5% Injection. Administration routes: Unknown, Subcutaneous, Parenteral, Intramuscular.

By species: Cattle (148 reports), Human (39 reports), Unknown (35 reports). By breed: Unknown (76), Aberdeen Angus (48), Cattle (unknown) (24).

Leading clinical signs: Lack of efficacy - NOS (38), Digestive tract disorder NOS (30), Lack of efficacy (endoparasite) - NOS (30), Death (26). Outcome, 199 coded reports: Outcome Unknown leads at 70.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.