Drug profile

The FDA adverse-event record for Eprinomectin 5% Injection

229 FDA reports name Eprinomectin 5% Injection, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#507 of 2,679
by report volume (all drugs)
229
adverse-event reports
12.7%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Eprinomectin 5% Injection ranks #506 of 2679 by total reports (229) and #433 of 1130 by death-coded share (12.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#506
This drug, reports of 2679
#433
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eprinomectin 5% Injection has 229 reports now versus 229 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eprinomectin 5% Injection changes

Signature read: death-coded report count at 29 is the most distinctive stamp on Eprinomectin 5% Injection's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
229
Total Reports
29
Deaths Reported
12.7%
Death-coded share of reports

Active Ingredients

Eprinomectin 5% Injection

Administration Routes

UnknownSubcutaneousParenteralIntramuscularOtherOphthalmicTopicalCutaneousOral

Species Affected

Cattle 149
Human 39
Unknown 35
Goat 4
Dog 1
Alpaca 1

Most Affected Breeds

Unknown 76
Aberdeen Angus 48
Cattle (unknown) 24
Cattle (other) 23
Crossbred Bovine/Cattle 17
Brangus 8
Holstein-Friesian also known as Holstein 5
Hereford cattle 4
Jersey 4
Goat (unknown) 3

Most Reported Reactions

Lack of efficacy - NOS 39
Digestive tract disorder NOS 30
Lack of efficacy (endoparasite) - NOS 30
Death 27
Low weight gain 24
Injection site lesion 24
Injection site swelling 19
INEFFECTIVE, PARASITE(S) NOS 14
Uncoded sign 14
Unthrifty 12
Poor coat condition 11
Skin lesion NOS 10

Outcome Breakdown

Outcome Unknown
141 (69.8%)
Died
28 (13.9%)
Recovered/Normal
24 (11.9%)
Ongoing
7 (3.5%)
Euthanized
1 (0.5%)
Recovered with Sequela
1 (0.5%)

Eprinomectin 5% Injection: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Eprinomectin 5% Injection, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (12.7% here), distinct from the volume row.

What to do with this drug

  • Compare Eprinomectin 5% Injection's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eprinomectin 5% Injection (#507 of 2,679 by report volume); death-coded 12.7%. PlainBreed drug row · death-coded report count stamp 29 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →