Drug profile

The FDA adverse-event record for Eprinomectin 0.5% Pour-On

151 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eprinomectin 0.5% Pour-On. See the species affected, top reactions, and outcomes below.

151
adverse-event reports
4.0%
death-coded share
Cattle
most-reported species
44
Uncoded sign - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
151
Total Reports
6
Deaths Reported
4.0%
Death Rate

Active Ingredients

Eprinomectin 0.5% Pour-On

Administration Routes

UnknownTopicalOralOther

Species Affected

Cattle 82
Unknown 50
Dog 9
Human 4
Cat 3
Pig 1
Goat 1
Other 1

Most Affected Breeds

Unknown 56
Holstein-Friesian also known as Holstein 21
Aberdeen Angus 17
Cattle (unknown) 16
Cattle (other) 13
Crossbred Bovine/Cattle 7
Charolais 3
Cat (unknown) 3
Retriever - Labrador 3
Hereford cattle 2

Most Reported Reactions

Uncoded sign 44
Lack of efficacy (ectoparasite) - lice 35
Lack of efficacy - NOS 30
Scratching 20
Hair loss NOS 20
Skin disorders NOS 18
Itching 16
Product Defect, General 11
Containers, Damaged 10
Caps, Abnormal 9
General hair loss 9
Pruritus 8

Outcome Breakdown

Outcome Unknown
88 (86.3%)
Recovered/Normal
5 (4.9%)
Died
5 (4.9%)
Ongoing
2 (2.0%)
Recovered with Sequela
1 (1.0%)
Euthanized
1 (1.0%)

Eprinomectin 0.5% Pour-On Adverse Event Insights

151 reports name Eprinomectin 0.5% Pour-On; 6 recorded a death outcome (4.0% of reported events, not a population-level mortality rate). Active ingredient: Eprinomectin 0.5% Pour-On. Administration routes: Unknown, Topical, Oral, Other.

By species: Cattle (82 reports), Unknown (50 reports), Dog (9 reports). By breed: Unknown (56), Holstein-Friesian also known as Holstein (21), Aberdeen Angus (17).

Leading clinical signs: Uncoded sign (44), Lack of efficacy (ectoparasite) - lice (35), Lack of efficacy - NOS (30), Scratching (20). Outcome, 102 coded reports: Outcome Unknown leads at 86.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.