Drug profile

The FDA adverse-event record for Eprinomectin 0.5% Pour-On

151 FDA reports name Eprinomectin 0.5% Pour-On, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#627 of 2,679
by report volume (all drugs)
151
adverse-event reports
4.0%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Eprinomectin 0.5% Pour-On ranks #627 of 2679 by total reports (151) and #848 of 1130 by death-coded share (4.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#627
This drug, reports of 2679
#848
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eprinomectin 0.5% Pour-On has 151 reports now versus 151 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eprinomectin 0.5% Pour-On changes

Signature read: 151 reports place Eprinomectin 0.5% Pour-On in the upper third of FDA AER volume (#627 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
151
Total Reports
6
Deaths Reported
4.0%
Death-coded share of reports

Active Ingredients

Eprinomectin 0.5% Pour-On

Administration Routes

UnknownTopicalOralOther

Species Affected

Cattle 82
Unknown 50
Dog 9
Human 4
Cat 3
Pig 1
Goat 1
Other 1

Most Affected Breeds

Unknown 56
Holstein-Friesian also known as Holstein 21
Aberdeen Angus 17
Cattle (unknown) 16
Cattle (other) 13
Crossbred Bovine/Cattle 7
Charolais 3
Cat (unknown) 3
Retriever - Labrador 3
Hereford cattle 2

Most Reported Reactions

Uncoded sign 44
Lack of efficacy (ectoparasite) - lice 35
Lack of efficacy - NOS 30
Scratching 20
Hair loss NOS 20
Skin disorders NOS 18
Itching 16
Product Defect, General 11
Containers, Damaged 10
Caps, Abnormal 9
General hair loss 9
Pruritus 8

Outcome Breakdown

Outcome Unknown
88 (86.3%)
Died
5 (4.9%)
Recovered/Normal
5 (4.9%)
Ongoing
2 (2.0%)
Recovered with Sequela
1 (1.0%)
Euthanized
1 (1.0%)

Eprinomectin 0.5% Pour-On: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Eprinomectin 0.5% Pour-On, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Eprinomectin 0.5% Pour-On's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eprinomectin 0.5% Pour-On (#627 of 2,679 by report volume); death-coded 4.0%. PlainBreed drug row · report volume stamp 151 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →