Drug profile

The FDA adverse-event record for Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum

Name: Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

12 FDA reports name Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2344 of 2,679
by report volume (all drugs): 12
adverse-event reports: 25.0%
death-coded share: Dog
most-reported species

Compiled by PlainBreed

Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum ranks #2299 of 2679 by total reports (12). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1): 97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1): #2299
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum has 12 reports now versus 12 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum changes

Signature read: 12 reports place Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum in the lower third of FDA AER volume (#2344 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

25.0%

Death-coded share of reports

Active Ingredients

Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum

Administration Routes

Unknown

Species Affected

Dog 12

Most Affected Breeds

Retriever - Labrador 4

Chihuahua 1

Unknown 1

Boxer (German Boxer) 1

Dog (other) 1

Shih Tzu 1

Retriever - Golden 1

Terrier - Jack Russell 1

Sheepdog - Shetland 1

Most Reported Reactions

Diarrhoea 9

Vomiting 7

Decreased appetite 3

Lethargy (see also Central nervous system depression in 'Neurological') 3

Dehydration 2

Death by euthanasia 2

Abnormal ultrasound finding 2

Proteinuria 2

Partial anorexia 2

Anorexia 2

Bloody diarrhoea 2

Weakness 2

Outcome Breakdown

Ongoing

4 (33.3%)

Recovered/Normal

3 (25.0%)

Euthanized

2 (16.7%)

Outcome Unknown

2 (16.7%)

Died

1 (8.3%)

Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Enterococcus Faecium, Streptococcus Thermophilus, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Lactobacillus Casei, Bifidobacterium Bifidum, And Lactobacillus Plantarum (#2344 of 2,679 by report volume); death-coded 25.0%. PlainBreed drug row · report volume stamp 12 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →