Drug profile

The FDA adverse-event record for Enrofloxacin & Silver Sulfadiazine

30 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Enrofloxacin & Silver Sulfadiazine. See the species affected, top reactions, and outcomes below.

30
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
8
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
30
Total Reports
4
Deaths Reported
13.3%
Death Rate

Active Ingredients

Enrofloxacin & Silver Sulfadiazine

Administration Routes

Auricular (Otic)UnknownTopical

Species Affected

Dog 22
Cat 8

Most Affected Breeds

Retriever - Labrador 6
Domestic Shorthair 5
Bulldog 3
Shih Tzu 3
Terrier (unspecified) 2
Terrier - Yorkshire 2
Griffon - Brussels 1
Maine Coon 1
Hound - Basset 1
Persian 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 8
Other abnormal test result NOS 5
Abnormal radiograph finding 5
Anaemia NOS 4
Vomiting 4
Death by euthanasia 4
Neutrophilia 3
Anorexia 3
Shock 3
Abdominal cavity haemorrhage 3
Splenic neoplasm 3
Facial swelling (see also 'Skin') 3

Outcome Breakdown

Ongoing
18 (60.0%)
Recovered/Normal
5 (16.7%)
Euthanized
4 (13.3%)
Outcome Unknown
3 (10.0%)

Enrofloxacin & Silver Sulfadiazine Adverse Event Insights

30 reports name Enrofloxacin & Silver Sulfadiazine; 4 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). Active ingredient: Enrofloxacin & Silver Sulfadiazine. Administration routes: Auricular (Otic), Unknown, Topical.

By species: Dog (22 reports), Cat (8 reports). By breed: Retriever - Labrador (6), Domestic Shorthair (5), Bulldog (3).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (8), Other abnormal test result NOS (5), Abnormal radiograph finding (5), Anaemia NOS (4). Outcome, 30 coded reports: Ongoing leads at 60.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.