Drug profile

The FDA adverse-event record for Emodepside/Praziquantel

98 FDA reports name Emodepside/Praziquantel, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#784 of 2,679
by report volume (all drugs)
98
adverse-event reports
16.3%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Emodepside/Praziquantel ranks #784 of 2679 by total reports (98) and #330 of 1130 by death-coded share (16.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#784
This drug, reports of 2679
#330
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Emodepside/Praziquantel has 98 reports now versus 98 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Emodepside/Praziquantel changes

Signature read: death-coded report count at 16 is the most distinctive stamp on Emodepside/Praziquantel's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
98
Total Reports
16
Deaths Reported
16.3%
Death-coded share of reports

Active Ingredients

Emodepside/Praziquantel

Administration Routes

UnknownTopicalOral

Species Affected

Cat 72
Unknown 25
Dog 1

Most Affected Breeds

Domestic Shorthair 48
Unknown 25
Domestic Longhair 8
Cat (other) 6
Domestic Mediumhair 5
Ragdoll 3
Maine Coon 1
Bengal 1
Chihuahua 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 16
Application site alopecia 11
Product Defect, General 9
Death by euthanasia 8
Vomiting 7
Underfilling, Package 7
Anorexia 6
Uncoded sign 6
Behavioural disorder NOS 5
Febrile 5
Ataxia 5
Death 5

Outcome Breakdown

Ongoing
31 (41.9%)
Outcome Unknown
22 (29.7%)
Euthanized
9 (12.2%)
Died
7 (9.5%)
Recovered/Normal
5 (6.8%)

Emodepside/Praziquantel: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Emodepside/Praziquantel, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (16.3% here), distinct from the volume row.

What to do with this drug

  • Compare Emodepside/Praziquantel's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Emodepside/Praziquantel (#784 of 2,679 by report volume); death-coded 16.3%. PlainBreed drug row · death-coded report count stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →