Drug profile

The FDA adverse-event record for Emodepside/Praziquantel

98 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Emodepside/Praziquantel. See the species affected, top reactions, and outcomes below.

98
adverse-event reports
16.3%
death-coded share
Cat
most-reported species
16
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
98
Total Reports
16
Deaths Reported
16.3%
Death Rate

Active Ingredients

Emodepside/Praziquantel

Administration Routes

UnknownTopicalOral

Species Affected

Cat 72
Unknown 25
Dog 1

Most Affected Breeds

Domestic Shorthair 48
Unknown 25
Domestic Longhair 8
Cat (other) 6
Domestic Mediumhair 5
Ragdoll 3
Maine Coon 1
Bengal 1
Chihuahua 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 16
Application site alopecia 11
Product Defect, General 9
Death by euthanasia 8
Vomiting 7
Underfilling, Package 7
Anorexia 6
Uncoded sign 6
Behavioural disorder NOS 5
Febrile 5
Ataxia 5
Death 5

Outcome Breakdown

Ongoing
31 (41.9%)
Outcome Unknown
22 (29.7%)
Euthanized
9 (12.2%)
Died
7 (9.5%)
Recovered/Normal
5 (6.8%)

Emodepside/Praziquantel Adverse Event Insights

98 reports name Emodepside/Praziquantel; 16 recorded a death outcome (16.3% of reported events, not a population-level mortality rate). Active ingredient: Emodepside/Praziquantel. Administration routes: Unknown, Topical, Oral.

By species: Cat (72 reports), Unknown (25 reports), Dog (1 reports). By breed: Domestic Shorthair (48), Unknown (25), Domestic Longhair (8).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (16), Application site alopecia (11), Product Defect, General (9), Death by euthanasia (8). Outcome, 74 coded reports: Ongoing leads at 41.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.