Drug profile

The FDA adverse-event record for Emodepside + Praziquantel

4,931 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Emodepside + Praziquantel. See the species affected, top reactions, and outcomes below.

4,931
adverse-event reports
4.3%
death-coded share
Cat
most-reported species
1,127
Application site alopecia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
4,931
Total Reports
214
Deaths Reported
4.3%
Death Rate

Active Ingredients

EmodepsidePraziquantel

Administration Routes

TopicalUnknownOralOtherOphthalmicTransdermalIntraocularSubcutaneous

Species Affected

Cat 4,589
Unknown 232
Human 72
Dog 36
Rabbit 1
Whale 1

Most Affected Breeds

Domestic Shorthair 3,145
Cat (unknown) 496
Domestic Longhair 322
Unknown 313
Domestic Mediumhair 301
Siamese 92
Maine Coon 46
Bengal 29
Russian 20
Ragdoll 18

Most Reported Reactions

Application site alopecia 1,127
Hypersalivation 827
Lethargy (see also Central nervous system depression in 'Neurological') 656
Vomiting 463
Ataxia 386
Lack of efficacy (endoparasite) - tapeworm 384
Behavioural disorder NOS 334
Anorexia 300
Application site erythema 267
Application site pruritus 265
Licking at application site 217
Accidental exposure 195

Outcome Breakdown

Outcome Unknown
2,622 (55.8%)
Recovered/Normal
1,574 (33.5%)
Ongoing
286 (6.1%)
Died
131 (2.8%)
Euthanized
83 (1.8%)
Recovered with Sequela
7 (0.1%)

Emodepside + Praziquantel Adverse Event Insights

4,931 reports name Emodepside + Praziquantel; 214 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). Active ingredients: Emodepside, Praziquantel. Administration routes: Topical, Unknown, Oral, Other.

By species: Cat (4,589 reports), Unknown (232 reports), Human (72 reports). By breed: Domestic Shorthair (3,145), Cat (unknown) (496), Domestic Longhair (322).

Leading clinical signs: Application site alopecia (1,127), Hypersalivation (827), Lethargy (see also Central nervous system depression in 'Neurological') (656), Vomiting (463). Outcome, 4,703 coded reports: Outcome Unknown leads at 55.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.