Drug profile

The FDA adverse-event record for Doxorubicin

40 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Doxorubicin. See the species affected, top reactions, and outcomes below.

40
adverse-event reports
25.0%
death-coded share
Dog
most-reported species
10
Anorexia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
40
Total Reports
10
Deaths Reported
25.0%
Death Rate

Active Ingredients

Doxorubicin

Administration Routes

UnknownIntravenousOralParenteral

Species Affected

Dog 39
Cat 1

Most Affected Breeds

Retriever - Golden 6
Crossbred Canine/dog 5
Dog (unknown) 4
Retriever - Labrador 4
Boxer (German Boxer) 2
Spaniel (unspecified) 2
Pit Bull 2
Beagle 2
Weimaraner 1
Terrier (unspecified) 1

Most Reported Reactions

Anorexia 10
Diarrhoea 10
Death by euthanasia 9
Lack of efficacy - NOS 9
Weight loss 8
Thrombocytopenia 5
Vomiting 5
Lethargy (see also Central nervous system depression in 'Neurological') 5
Decreased appetite 5
Lethargy (see also Central nervous system depression in Neurological) 5
Neutropenia 4
Urinary incontinence 3

Outcome Breakdown

Outcome Unknown
15 (37.5%)
Ongoing
12 (30.0%)
Euthanized
8 (20.0%)
Recovered/Normal
3 (7.5%)
Died
2 (5.0%)

Doxorubicin Adverse Event Insights

40 reports name Doxorubicin; 10 recorded a death outcome (25.0% of reported events, not a population-level mortality rate). Active ingredient: Doxorubicin. Administration routes: Unknown, Intravenous, Oral, Parenteral.

By species: Dog (39 reports), Cat (1 reports). By breed: Retriever - Golden (6), Crossbred Canine/dog (5), Dog (unknown) (4).

Leading clinical signs: Anorexia (10), Diarrhoea (10), Death by euthanasia (9), Lack of efficacy - NOS (9). Outcome, 40 coded reports: Outcome Unknown leads at 37.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.