Drug profile

The FDA adverse-event record for Distemper Combination Vaccine

49 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Distemper Combination Vaccine. See the species affected, top reactions, and outcomes below.

49
adverse-event reports
8.2%
death-coded share
Dog
most-reported species
11
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
49
Total Reports
4
Deaths Reported
8.2%
Death Rate

Active Ingredients

Distemper Combination Vaccine

Administration Routes

UnknownSubcutaneous

Species Affected

Dog 44
Cat 5

Most Affected Breeds

Retriever - Labrador 5
Beagle 4
Domestic Shorthair 3
Retriever - Golden 3
Crossbred Canine/dog 3
Ridgeback - Rhodesian 3
Boxer (German Boxer) 2
Chihuahua 2
Terrier - Yorkshire 2
Spitz - German Pomeranian 2

Most Reported Reactions

Vomiting 11
Anorexia 11
Other abnormal test result NOS 7
Emesis (multiple) 7
Lethargy (see also Central nervous system depression in 'Neurological') 6
Diarrhoea 4
Weight gain 3
Panting 3
INEFFECTIVE, HEARTWORM LARVAE 3
Hyperactivity 3
Vocalisation 3
Barking 3

Outcome Breakdown

Recovered/Normal
22 (44.9%)
Outcome Unknown
19 (38.8%)
Ongoing
4 (8.2%)
Euthanized
2 (4.1%)
Died
2 (4.1%)

Distemper Combination Vaccine Adverse Event Insights

49 reports name Distemper Combination Vaccine; 4 recorded a death outcome (8.2% of reported events, not a population-level mortality rate). Active ingredient: Distemper Combination Vaccine. Administration routes: Unknown, Subcutaneous.

By species: Dog (44 reports), Cat (5 reports). By breed: Retriever - Labrador (5), Beagle (4), Domestic Shorthair (3).

Leading clinical signs: Vomiting (11), Anorexia (11), Other abnormal test result NOS (7), Emesis (multiple) (7). Outcome, 49 coded reports: Recovered/Normal leads at 44.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.