Drug profile

The FDA adverse-event record for Distemper Combination Vaccine

49 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Distemper Combination Vaccine. Species, reactions, and outcomes follow.

#1134 of 2,679
by report volume (all drugs)
49
adverse-event reports
8.2%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Distemper Combination Vaccine ranks #1131 of 2679 by total reports (49). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1131
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Distemper Combination Vaccine has 49 reports now versus 49 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Distemper Combination Vaccine changes

Signature read: death-coded share at 8.2% is the most distinctive stamp on Distemper Combination Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
49
Total Reports
4
Deaths Reported
8.2%
Death-coded share of reports

Active Ingredients

Distemper Combination Vaccine

Administration Routes

UnknownSubcutaneous

Species Affected

Dog 44
Cat 5

Most Affected Breeds

Retriever - Labrador 5
Beagle 4
Domestic Shorthair 3
Retriever - Golden 3
Crossbred Canine/dog 3
Ridgeback - Rhodesian 3
Boxer (German Boxer) 2
Chihuahua 2
Terrier - Yorkshire 2
Spitz - German Pomeranian 2

Most Reported Reactions

Vomiting 11
Anorexia 11
Other abnormal test result NOS 7
Emesis (multiple) 7
Lethargy (see also Central nervous system depression in 'Neurological') 6
Diarrhoea 4
Weight gain 3
Panting 3
INEFFECTIVE, HEARTWORM LARVAE 3
Hyperactivity 3
Vocalisation 3
Barking 3

Outcome Breakdown

Recovered/Normal
22 (44.9%)
Outcome Unknown
19 (38.8%)
Ongoing
4 (8.2%)
Euthanized
2 (4.1%)
Died
2 (4.1%)

Distemper Combination Vaccine Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Distemper Combination Vaccine (#1134 of 2,679 by report volume); death-coded 8.2%. PlainBreed drug row · death-coded share stamp 8.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →