Drug profile

The FDA adverse-event record for Dinotefuran/Permethrin/Pyriproxyfen

20 FDA reports name Dinotefuran/Permethrin/Pyriproxyfen, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1790 of 2,679
by report volume (all drugs)
20
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dinotefuran/Permethrin/Pyriproxyfen ranks #1778 of 2679 by total reports (20). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1778
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dinotefuran/Permethrin/Pyriproxyfen has 20 reports now versus 20 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dinotefuran/Permethrin/Pyriproxyfen changes

Signature read: Dinotefuran/Permethrin/Pyriproxyfen's 0.0% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
0
Deaths Reported
0.0%
Death-coded share of reports

Active Ingredients

Dinotefuran/Permethrin/Pyriproxyfen

Administration Routes

TopicalUnknown

Species Affected

Dog 20

Most Affected Breeds

Spitz - German Pomeranian 3
Retriever - Labrador 2
Greyhound - Italian 1
Chihuahua 1
Doberman Pinscher 1
Terrier - Bull - Staffordshire 1
Beagle 1
Pug 1
Spaniel - Springer English 1
Lhasa Apso 1

Most Reported Reactions

Vomiting 8
Other abnormal test result NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 4
Twitching 2
Diarrhoea 2
Anorexia 2
Shaking 2
Papule 1
Skin lesion NOS 1
Hair loss NOS 1
Agitation 1
Hyperactivity 1

Outcome Breakdown

Recovered/Normal
12 (60.0%)
Ongoing
4 (20.0%)
Outcome Unknown
4 (20.0%)

Dinotefuran/Permethrin/Pyriproxyfen: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dinotefuran/Permethrin/Pyriproxyfen (#1790 of 2,679 by report volume); death-coded 0.0%. PlainBreed drug row · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →