Dinotefuran + Pyriproxyfen + Permethrin
214 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
214
Total Reports
8
Deaths Reported
370.0%
Death Rate
Active Ingredients
Dinotefuran + Pyriproxyfen + Permethrin
Administration Routes
TopicalUnknownOralCutaneousAuricular (Otic)
Species Affected
Dog 213
Cat 1
Most Affected Breeds
Retriever - Labrador 35
Retriever - Golden 16
Shepherd Dog - German 13
Crossbred Canine/dog 13
Shih Tzu 9
Dachshund (unspecified) 8
Shepherd Dog - Australian 7
Terrier - Yorkshire 7
Beagle 6
Terrier (unspecified) 6
Most Reported Reactions
Vomiting 46
Lack of efficacy (endoparasite) - heartworm 33
Lethargy (see also Central nervous system depression in 'Neurological') 28
Diarrhoea 22
Other abnormal test result NOS 16
Lack of efficacy (endoparasite) - hookworm 15
Not eating 13
Lack of efficacy (bacteria) - Borrelia 13
Lack of efficacy - NOS 12
Emesis 11
Behavioural disorder NOS 9
Seizure NOS 8
Outcome Breakdown
Outcome Unknown
116 (54.2%)
Recovered/Normal
57 (26.6%)
Ongoing
31 (14.5%)
Euthanized
6 (2.8%)
Recovered with Sequela
2 (0.9%)
Died
2 (0.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.