Drug profile

The FDA adverse-event record for Dihydrostreptomycin, Penicillin G Procaine

27 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dihydrostreptomycin, Penicillin G Procaine. See the species affected, top reactions, and outcomes below.

27
adverse-event reports
14.8%
death-coded share
Cattle
most-reported species
6
Residues in milk - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
27
Total Reports
4
Deaths Reported
14.8%
Death Rate

Active Ingredients

Dihydrostreptomycin, Penicillin G Procaine

Administration Routes

UnknownIntramammaryOral

Species Affected

Cattle 15
Unknown 12

Most Affected Breeds

Unknown 12
Holstein-Friesian also known as Holstein 10
Cattle (unknown) 2
Jersey 1
Brahman 1
Cattle (other) 1

Most Reported Reactions

Residues in milk 6
Residues in meat/offal 5
Underfilling, Package 5
DEATH-SLAUGHTERED 3
Caps, Abnormal 3
Tubes, Leaking 3
Product syringe issue 2
Tubes, Damaged 2
Lack of efficacy - NOS 1
Missing Cap 1
Lack of efficacy (bacteria) - NOS 1
Mammary gland disorder NOS 1

Outcome Breakdown

Died
4 (100.0%)

Dihydrostreptomycin, Penicillin G Procaine Adverse Event Insights

27 reports name Dihydrostreptomycin, Penicillin G Procaine; 4 recorded a death outcome (14.8% of reported events, not a population-level mortality rate). Active ingredient: Dihydrostreptomycin, Penicillin G Procaine. Administration routes: Unknown, Intramammary, Oral.

By species: Cattle (15 reports), Unknown (12 reports). By breed: Unknown (12), Holstein-Friesian also known as Holstein (10), Cattle (unknown) (2).

Leading clinical signs: Residues in milk (6), Residues in meat/offal (5), Underfilling, Package (5), DEATH-SLAUGHTERED (3). Outcome, 4 coded reports: Died leads at 100.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.