Drug profile

The FDA adverse-event record for Dietary Supplement (Unknown)

122 FDA reports name Dietary Supplement (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#702 of 2,679
by report volume (all drugs)
122
adverse-event reports
4.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dietary Supplement (Unknown) ranks #702 of 2679 by total reports (122) and #796 of 1130 by death-coded share (4.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#702
This drug, reports of 2679
#796
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dietary Supplement (Unknown) has 122 reports now versus 121 in that prior snapshot: 1 more (0.8%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dietary Supplement (Unknown) changes

Signature read: 122 reports place Dietary Supplement (Unknown) in the upper third of FDA AER volume (#702 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
122
Total Reports
6
Deaths Reported
4.9%
Death-coded share of reports

Active Ingredients

Dietary Supplement (Unknown)

Administration Routes

OralUnknownOphthalmic

Species Affected

Dog 92
Cat 26
Human 2
Horse 1
Cattle 1

Most Affected Breeds

Domestic Shorthair 14
Retriever - Labrador 8
Shepherd Dog - Australian 7
Collie - Border 6
Crossbred Canine/dog 5
Cat (unknown) 5
Terrier - West Highland White 4
Retriever - Golden 4
Chihuahua 3
Siberian Husky 3

Most Reported Reactions

Emesis 23
Vomiting 18
Lack of efficacy - NOS 17
Lethargy (see also Central nervous system depression in 'Neurological') 17
Lack of efficacy (ectoparasite) - flea 15
Diarrhoea 15
Not eating 10
Weight loss 9
Scratching 6
Behavioural disorder NOS 6
Other abnormal test result NOS 6
Weight gain 5

Outcome Breakdown

Recovered/Normal
45 (36.9%)
Outcome Unknown
37 (30.3%)
Ongoing
24 (19.7%)
Recovered with Sequela
10 (8.2%)
Died
3 (2.5%)
Euthanized
3 (2.5%)

Dietary Supplement (Unknown): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dietary Supplement (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Dietary Supplement (Unknown)'s report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dietary Supplement (Unknown) (#702 of 2,679 by report volume); death-coded 4.9%. PlainBreed drug row · report volume stamp 122 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →