Drug profile

The FDA adverse-event record for Dextromethorphan + Guaifenisen

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dextromethorphan + Guaifenisen. See the species affected, top reactions, and outcomes below.

15
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
6
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
2
Deaths Reported
13.3%
Death Rate

Active Ingredients

Dextromethorphan + Guaifenisen

Administration Routes

OralUnknown

Species Affected

Dog 15

Most Affected Breeds

Retriever - Labrador 3
Dachshund (unspecified) 2
Setter - English 1
Chihuahua 1
Sheepdog - Old English 1
Pekingese 1
Pit Bull 1
Terrier (unspecified) 1
Great Pyrenees 1
Spitz - German Pomeranian 1

Most Reported Reactions

Emesis 6
Seizure NOS 3
Vomiting 3
Cough 2
Death 2
Weight loss 2
Respiratory tract infection NOS 2
Syncope 1
Breathing difficulty 1
Disorientation 1
Lethargy (see also Central nervous system depression in 'Neurological') 1
Bladder incontinence 1

Outcome Breakdown

Recovered/Normal
9 (60.0%)
Outcome Unknown
3 (20.0%)
Died
2 (13.3%)
Ongoing
1 (6.7%)

Dextromethorphan + Guaifenisen Adverse Event Insights

15 reports name Dextromethorphan + Guaifenisen; 2 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). Active ingredient: Dextromethorphan + Guaifenisen. Administration routes: Oral, Unknown.

By species: Dog (15 reports). By breed: Retriever - Labrador (3), Dachshund (unspecified) (2), Setter - English (1).

Leading clinical signs: Emesis (6), Seizure NOS (3), Vomiting (3), Cough (2). Outcome, 15 coded reports: Recovered/Normal leads at 60.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.