Drug profile

The FDA adverse-event record for Dexmedetomidine,Ketamine,Butorphanol

111 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dexmedetomidine,Ketamine,Butorphanol. See the species affected, top reactions, and outcomes below.

111
adverse-event reports
12.6%
death-coded share
Cat
most-reported species
21
Behavioural disorder NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
111
Total Reports
14
Deaths Reported
12.6%
Death Rate

Active Ingredients

Dexmedetomidine,Ketamine,Butorphanol

Administration Routes

UnknownParenteralIntramuscularOther

Species Affected

Cat 109
Dog 2

Most Affected Breeds

Domestic Shorthair 72
Domestic Longhair 9
Cat (unknown) 8
Domestic Mediumhair 8
Siamese 5
Dog (unknown) 1
British cat 1
Bengal 1
Rex (unspecified) 1
Scottish Fold Shorthair 1

Most Reported Reactions

Behavioural disorder NOS 21
Hyperactivity 18
Dilated pupils 14
Not eating 12
Dysphoria 12
Elevated temperature 11
Lethargy (see also Central nervous system depression in Neurological) 10
Hiding 9
Not sleeping 9
Application site alopecia 8
Seizure NOS 7
Weight loss 7

Outcome Breakdown

Ongoing
38 (34.2%)
Recovered/Normal
32 (28.8%)
Outcome Unknown
27 (24.3%)
Euthanized
7 (6.3%)
Died
7 (6.3%)

Dexmedetomidine,Ketamine,Butorphanol Adverse Event Insights

111 reports name Dexmedetomidine,Ketamine,Butorphanol; 14 recorded a death outcome (12.6% of reported events, not a population-level mortality rate). Active ingredient: Dexmedetomidine,Ketamine,Butorphanol. Administration routes: Unknown, Parenteral, Intramuscular, Other.

By species: Cat (109 reports), Dog (2 reports). By breed: Domestic Shorthair (72), Domestic Longhair (9), Cat (unknown) (8).

Leading clinical signs: Behavioural disorder NOS (21), Hyperactivity (18), Dilated pupils (14), Not eating (12). Outcome, 111 coded reports: Ongoing leads at 34.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.