Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate

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14 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
14
Total Reports
1
Deaths Reported
710.0%
Death Rate

Active Ingredients

Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate

Administration Routes

UnknownOphthalmicTopicalIntraocular

Species Affected

Dog 14

Most Affected Breeds

Maltese 4
Crossbred Canine/dog 3
Poodle - Miniature 1
Shiba Inu 1
Retriever - Labrador 1
Terrier - West Highland White 1
Shih Tzu 1
Bulldog - English 1
Boxer (German Boxer) 1

Most Reported Reactions

Decreased appetite 3
Crust 3
Erythema (for urticaria see Immune SOC) 3
Lack of efficacy (endoparasite) - hookworm 3
Deafness 2
Elevated serum alkaline phosphatase (SAP) 2
Elevated alanine aminotransferase (ALT) 2
Elevated gamma-glutamyl transferase (GGT) 2
Local swelling (not application site) 2
Hyperpigmentation 2
Pinnae disorder 2
Loose stool 2

Outcome Breakdown

Outcome Unknown
8 (57.1%)
Ongoing
3 (21.4%)
Recovered with Sequela
1 (7.1%)
Recovered/Normal
1 (7.1%)
Died
1 (7.1%)

Data Summary

Metric Value
Total adverse event reports 14
Reports involving death 1
Case-fatality rate (reported events) 710.0%
Distinct species in reports 1
Distinct breeds in reports 9
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 14 adverse event reports referencing Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate, including 1 reports in which the animal died — a 710.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate. Reported administration routes include Unknown, Ophthalmic, Topical, Intraocular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate reports are Dog (14 reports), with Dog accounting for the largest share. Within those species, Maltese (4), Crossbred Canine/dog (3), Poodle - Miniature (1) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate are Decreased appetite (3), Crust (3), Erythema (for urticaria see Immune SOC) (3), Lack of efficacy (endoparasite) - hookworm (3). Of the 14 reports with a coded outcome, Outcome Unknown is the leading category at 57.1%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial